Russian Heart Failure Journal 2011year Arterial wall structure and functions in patients with chronic heart failure of ischemic etiology depending on level of left ventricular ejection fraction


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2011/

Arterial wall structure and functions in patients with chronic heart failure of ischemic etiology depending on level of left ventricular ejection fraction

Koziolova N. A., Cherniavina A. I., Surovtseva M. V., Eltsova M. A.

Keywords: arterial stiffness, left ventricle, EF, CHF

DOI: 10.18087/ rhfj.2011.6.1602

Relevance. Processes of revascularization include proliferation of artery smooth muscle cells with the further increase of their rigidity, as well as the change of intercellular matrix with the increase of media collagen content and the subsequent development of fibrosis. In this connection, studying of arterial wall fibrosis markers in patients with CHF became of higher interest. Purpose. The study of structure and functional features of arterial wall in patients with CHF of ischemic etiology. Materials and methods. 90 patients with stable II–III class CHF of ischemic etiology were enrolled to the study. Clinical symptoms were estimated by V. Yu. Mareev SHOKS scale (assessment scale of the clinical status), LV systolic function by Doppler EchoCG, artery conduction and damping functions by means of volume sphygmoplethysmography. Assays of NT-proBNP, c-terminal telopeptide of type 1 collagen and tissue inhibitor of matrix metalloproteinase-1 was determined. Results. Abnormal structure and functions of arterial wall was registered both in patients with preserved and decreased LVEF, and it was characterized by increased vascular wall stiffness, decreased elasticity and extensibility, one of its development factors was damage of the artery collagen intercellular matrix structure. Change of arterial wall depended on CHF severity (first of all, NT-proBNP level) and functional class of stable angina.
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Koziolova N.A., Cherniavina A.I., Surovtseva M.V. et al. Arterial wall structure and functions in patients with chronic heart failure of ischemic etiology depending on level of left ventricular ejection fraction. Russian Heart Failure Journal. 2011;12(6):350-354.

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