Russian Heart Failure Journal 2011year Importance of arteria hardness, central return wave values and vasculomotor functions of microvasculature endothelium at CHF of different etiology and failure severity

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Importance of arteria hardness, central return wave values and vasculomotor functions of microvasculature endothelium at CHF of different etiology and failure severity

Osmolovskaya Yu. F.1, Mareyev V. Yu.2, Glechan А. M.1, Balachonova T. V.1
1 – Federal State Budgetary Institution, “Russian Cardiology Research and Production Complex” of the RF Ministry of Health Care, 3rd Cherepkovskaya 15a, Moscow 121552
2 – Federal State Budgetary Educational Institution of Higher Professional Education “M. V. Lomonosov Moscow State University”, Leninskie Gory 1, GSP-1, Moscow 119992

Keywords: circulatory decompensation, vessels hardnes, microcirculation, CHF, endothelial dysfunction

DOI: 10.18087/ rhfj.2011.5.1584

Relevancy. Increase of vessels hardness approved one of the mechanisms underlying an increase of systolic and pulse pressure and as a result became an important causative factor of cardiovascular diseases. However today we have an insufficient study of the significance of vessels hardness, central return wave as well as endothelial function of microvasculature at CHF with safe and reduced systolic function of left ventricle. Objective. Evaluation of vessels hardness and endothelial function of microvasculature and their significance at CHF with safe (CHF–cardiovascular function) and reduced systolic function (SCHF) of left ventricle of a different ethiology and failure severity. Materials and methods. This research included 134 CHF I–IV FC NYHA patients with sinoatrial rate and 30 non – CHF patients included into the control group. CHF patients were divided into two subgroups: patients with ejection fraction of <40 % (SCHF, n=84) and with ejection fraction of <45 % and proved diastolic dysfunction (CHF–cardiovasculare function, n=50). Evaluation of the vessels hardness were made by the method of applanation tonometry: evaluation of pulse-wave velocity (PWV) on a carotic femoral section, characteristics of central return wave (in aorta): average arteriotony, central systolic arteriotony, central pulse pressure, central diastolic pressure, augmentation index, augmentation index / heart rate 75. Vasculomotor function of microvasculature endothelium or microvasculature vasculoreactivity was defined by photoplethysmography of nail bed vessels at the initial stage and reactive hyperemia phase. Evaluation of the clinical state was carried out based on the results of the 6 minutes walking test, Minnesotan QOL questionnaire, rating scale of a clinical state. All patients received recommended CHF therapy. Results. While increasing CHF severity, both at safe and reduced contractile function of left ventricle there is a decrease of such indicants as vessels hardness, central return wave and microvasculature, however authentic relations with FC CHF are revealed for pulse-wave velocity (PWV) only. SCHF patient of associated age did not show the authentic relation of failure for such parameters as vessels hardness and central return wave with heart failure ethiology (ischemic heart disease / dilated cardiomyopathy); at that microvasculature failure were more expressed with ischemic heart disease patients as compared to dilated cardiomyopathy patients.
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Osmolovskaya Yu. F., Mareyev V. Yu., Glechan А. M. et al. Importance of arteria hardness, central return wave values and vasculomotor functions of microvasculature endothelium at CHF of different etiology and failure severity. Russian Heart Failure Journal. 2011;12(5):270-276.

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