Russian Heart Failure Journal 2011year Influence of therapy by selective beta1-blocker bisoprolol and selective beta1-blocker with NO-modeling nebivolol on myocardial collagen balance at CHF patients

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Influence of therapy by selective beta1-blocker bisoprolol and selective beta1-blocker with NO-modeling nebivolol on myocardial collagen balance at CHF patients

Zhubrina E. S., Ovchinnikov A. G., Seredina E. M., Masenko V. P., Ageyev F. T.
Federal State Budgetary Institution, “Russian Cardiology Research and Production Complex” of the RF Ministry of Health Care, 3rd Cherepkovskaya 15a, Moscow 121552

Keywords: beta-adrenergic blocker agents, collagen exchange, CHF

DOI: 10.18087/rhfj.2011.5.1570

Relevancy. Imbalance in myocardial collagen plays an important role in physiopathology of both systolic and diastolic heart failure. Objective. Evaluation of β1-adrenergic blocker agent of bisoprolol and β1-adrenergic blocker agent with NO-modeling properties of nebivolol influence on marker balance content of type I collagen. Materials and methods. 67 patients with stable CHF II–III FC, with reduced and safe systolic function of left ventricle, being at standard therapy, were randomized by groups treated by bisoprolol (n=35) or nebivolol (n=32). Initially and 6 months later after a therapy the patents were evaluated for clinical and haemodynamic status as well as for the level of C-terminal collagen propeptide of the type I (СICP), collagen synthesis marker of the type I and C-terminal collagen telopeptide, the type I (CITP), collagen deterioration marker of the type I, in blood serum. Results. Subgroups of CHF patients with safe and reduced (<50 %) function of left ventricle did not authentically differ by initial level of collagen change markers of the type I. Notwithstanding that CHF patients therapy by bisoprolol and nebivolol in equivalent doses was accompanied by comparable authentic improvement of clinical and haemodynamic status, the nebivolol group only showed the authentic reduce of CICP level, including patients both with diastolic and systolic CHF, by 12.8 and 13.1 % accordingly, as well as authentic reduce of CICP / CITP ratio (all р<0.05). Neither nebivolol group nor bisoprolol group showed authentic dynamic of CITP content. Thus the results of this research showed that despite comparable clinical efficiency of both specimens, nebivolol only demonstrated an authentic influence on collagen exchange for CHF patients both with safe and reduced function of left ventricle, relocating it towards collagen synthesis reduction of the type I.
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Zhubrina E. S., Ovchinnikov A. G., Seredina E. M. et al. Influence of therapy by selective beta1-blocker bisoprolol and selective beta1-blocker with NO-modeling nebivolol on myocardial collagen balance at CHF patients. Russian Heart Failure Journal. 2011;12(5):260-266.

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