Russian Heart Failure Journal 2011year Prognostic role of left ventricular diastolic dysfunction in patients with CAD and heart failure


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2011/

Prognostic role of left ventricular diastolic dysfunction in patients with CAD and heart failure

Hamuev Ya. P.
State Budgetary Educational Institution “I. M. Sechenov First Moscow State Medical University” of the RF Ministry of Health Care, Trubetskaya 8, Bld. 2, Moscow 119991

Keywords: left ventricular diastolic dysfunction, coronary artery disease, prognosis

DOI: 10.18087/rhfj.2011.2.1481

Background. Over the last decade the problem of LV diastolic dysfunction (DD) is highly relevant due to its high prevalence in population. 25–30 % of patients over 45 years have DD. Objective. To expand the assessment of prognosis in CAD patients with heart failure, taking into account clinical data, results of one-and two-dimensional echocardiography, pulsed wave and continuous-wave Doppler echocardiography, Doppler tissue imaging (DWT), ultrasound mapping of elastic arteries. To determine the most significant “related symptoms” to evaluate the prognosis in the model, connecting clinical presentation, echocardiographic data, ultrasound of arteries. Materials and methods. The study included 119 patients with CAD and heart failure II–IV FC (NYHA). The control group included patients with CAD without HF (n=162). All patients underwent echocardiographic studies: one-, two-dimensional echocardiography, Doppler echocardiography. Results. The prediction model of fatal outcome in the studied cohort of patients was developed with sensitivity of 81.8 % and specificity of 86.4 %. “Related symptoms” were picked out as the signs of poor prognosis with sensitivity of 92.0 % and specificity of 91.2 %.
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Hamuev Ya. P. Prognostic role of left ventricular diastolic dysfunction in patients with CAD and heart failure. Russian Heart Failure Journal. 2011;12(2):102-107.

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