Russian Heart Failure Journal 2011year The role of anemia in chronic heart failure flow in patients with dilated cardiomyopathy


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2011/№3

The role of anemia in chronic heart failure flow in patients with dilated cardiomyopathy

Abdullaev T. A., Tsoi I. A., Mardanov B. U.

Keywords: anemia, DCM, CHF

DOI: 10.18087 / rhfj.2011.3.1480

Background. Systemic manifestations of chronic heart failure and comorbid conditions (anemia, dysfunction of endocrine glands, renal and hepatic dysfunction, diabetes) have recently attracted increasing attention from researchers as they significantly affect the flow and prognosis of the main underlying disease. It is proved that anemia is common among patients with CHF and correlates with increased mortality and morbidity. Objective.To study the prevalence of anemia in patients with CHF due to dilated cardiomyopathy, as well as its relationship with clinical, hemodynamic and biochemical parameters. Materials and methods. Retrospective analysis of the survey of 210 patients with DCM (44.3±15.16 years). Patients were divided into two groups to assess the relationship between anemia and the main disease flow. Following parameters were analyzed: answers to SHOKS questionnaire, 6 min walk test, echocardiography, hemoglobin level and other biochemical parameters. Results. The prevalence of anemia in our study was 22.4 %. The presence of anemia burdens DCM flow, that appears in decreased exercise tolerance, and relatively worse hemodynamic parameters. Also a correlation between hemoglobin level and some markers of renal function and lipid profile was revealed.
  1. Elliott P, Andersson B, Arbustini E et al. Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2008;29 (2):270–276.
  2. Dickstein K. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: application of natriuretic peptides. Reply. Eur Heart J. 2008;24 (10):933–989.
  3. McMurray JJ, Stewart S. Epidemiology, actiology and prognosis of heart failure. Heart. 2000;83 (5):596–602.
  4. Anand IS, Kuskowski MA, Rector ThS et al. Anemia and Change in Hemoglobin Over Time Related to Mortality and Morbidity in Patients with chronic Heart Failure. Results from val-HeFT. Circulation. 2005;112 (8):1121–1127.
  5. Maggioni AP, Opasich C, Anand I et al. Anemia in patients with heart failure: prevalence and prognostic role in a controlled trial and in clinical practice. J Card Fail. 2005;11 (2):91–98.
  6. Ezekowitz JA, McAlister FA, Armstrong PW. Anemia is common in heart failure and is associated with poor outcomes: in sights from a cohort of 12065 patients with new-onset heart failure. Circulation. 2003;107 (2):223–225.
  7. Besarab A, Bolton WK, Browne JK et al. The effect of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin. N Engl J Med. 1998;339 (9):584–590.
  8. Mancini DM, Katz SD, Lang CC et al. Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure. Circulation. 2003;107 (2):294–299.
  9. Silverberg DS, Wexler D, Blum M et al. The effect of correction of anaemia in diabetics and non-diabetics with severe resistant congestive heart failure and chronic renal failure by subcutaneous erythropoietin and intravenous iron. Nephrol Dial Transplant. 2003;18 (1):141–146.
  10. Tang YD, Katz SD. Anemia in chronic heart failure. Prevalence, etiology, clinical correlates and treatment options. Circulation. 2006;113 (20):2454–2461.
  11. IV. NKF-K / DOQI Clinical Practice Guidelines for Anemia of Chronic Kidney Disease: update 2000. Am J Kidney Dis. 2001;37 (1 Suppl 1):S182–238.
  12. Komajda M, Anker SD, Charlesworth A et al. The impact of new onset anaemia on morbidity and mortality in chronic heart failure: results from COMET. Eur Heart J. 2006;27 (12):1440–1446.
  13. Tanner H, Moschovitis G, Kuster GM et al. The prevalence of anemia in chronic heart failure. Int J Cardiol. 2002;86 (1):115–121.
  14. Silverberg DS, Blum M, Peer G et al. Intravenous ferric saccharate as an iron supplement in dialysis patients. Nephron. 1996;72 (3):413–417.
  15. Wisniacki N, Aimson P, Lyle M. Is anemia a cause of heart failure in the elderly? Heart. 2001;85: (Suppl I):4.
  16. Anand I, McMurray JJ, Whitmore J et al. Anemia and its relationship to clinical outcome in heart failure. Circulation. 2004;110 (2):149–154.
  17. Ezekowits JA, McAlister FA, Armstrong PW. Anemia is common in heart failure and is associated with poor outcomes. Insights from a cohort of 12,065 patients with new-onset heart failure. Circulation. 2003;107 (2):223–225.
  18. Абдуллаев Т. А., Курбанов Н. А., Марданов Б. У. и др. Особенности течения дилатационной кардиомиопатии с очаговоподобными изменениями миокарда. Вестник аритмологии. 2009; 56: 31–36
  19. Шутов А. М., Тармонова Л. Ю., Чернышева Е. В., Альберт М. А. Кардио­ренальный анемический синдром у больных пожилого возраста. Нефрология и диализ. 2006;8 (4):350–354.
  20. O’Meara E, Clayton T, McEntegart MB et al. Clinical correlates and consequences of anemia in a broad spectrum of patients with heart failure: results of the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) Program. Circulation. 2006;113 (7):986–994.
  21. Арутюнов ГП. Анемия у больных с ХСН. Журнал Сердечная Недо­статочность. 2003;4 (5):224–228.
  22. Silverberg DS, Wexler D, Iaina A. The importance of anemia and its correction in the management of severe congestive heart failure. Eur J Heart Fail. 2002;4 (6):681–686.
  23. Silverberg DS, Wexler D, Blum M et al. The correction of anemia in severe resistant heart failure with erythropoietin and intravenous iron prevents the progression of both the heart and the renal failure and markedly reduces hospitalization. Clin Nephrol. 2002;58 (Suppl 1):S37–45.
  24. Сметанина И. Н., Деев А. Д., Грацианский Н. А. Уровни общего холе­стерина и глюкозы крови – факторы независимо связанные с риском смерти и госпитализации у больных с ХСН. Кардиология. 2007;47 (8):12–16.
Abdullaev T. A., Tsoi I. A., Mardanov B. U. The role of anemia in chronic heart failure flow in patients with dilated cardiomyopathy. Russian Heart Failure Journal. 2011;12(3):166-169

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