Russian Heart Failure Journal 2011year Express-method of diagnosis of renal tubulointersticial tissue lesion in CHF


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2011/

Express-method of diagnosis of renal tubulointersticial tissue lesion in CHF

Oganezova L.G.
State Budgetary Educational Institution of Higher Professional Education, “N.I. Pirogov Russian National Research Medical University” of the RF Ministry of Health Care, Ostrovityanova 1, Moscow 117997

Keywords: diagnosis, kidney, tubulointerstitial tissue, express-method

DOI: 10.18087/ rhfj.2011.1.1467

Background. Assessment of tubulointerstitial tissue (TIT) condition in CHF is very important as its impairment leads to reabsorption process impairment. Na+ delay is one of the leading factors in CHF progression as it appears long before significant reduction of glomerular filtration rate (GFR). Another important factor is endothelial dysfunction (ED). Objective. To develop a non-invasive express method for assessing the severity of TIT lesion in patients with CHF. Materials and methods. The pilot study included 32 patients with CHF I–II FC NYHA. The average age of 59.2±12.2 years, men – 25 %, hypertensive patients – 93.8 %, BMI – 28.5±5.76 kg / m2, systolic BP – 129.4±16.0 mmHg, diastolic BP – 83.4±11.8 mm Hg, serum creatinine level – 97.4±26.7 umol / l, 56.3 % received diuretics. In spot urine samples the level of Cl (equivalent to sodium excretion), nitrate-ion (metabolites of nitric oxide) with spectrophotometric analysis (CFA) was determined. Results. Cl level, obtained with SFA correlated with Na+ level (r=0.75, p<0.001). Estimated excretion of Na+ within 24 hours, measured by Cl excretion with SFA from a spot urine sample, correlated with Na+ excretion on laboratory data in 24‑h urine (r=0.76, p<0.05). Decreased urine nitrate-ion concentration with natriuresis reduction, indicated the progression of ED and ischemic TIT damage. Thus SFA can replace the 24‑hour urine collection and reflects the functional state of renal TIT in patients with CHF.
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Oganezova L.G. Express-method of diagnosis of renal tubulointersticial tissue lesion in CHF. Russian Heart Failure Journal. 2011;12(1):47-49

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