Russian Heart Failure Journal 2010year Prognostic impact of tissue inhibitor of matrix metalloproteinase-I (TIMP-I) in patients with CHF


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2010/

Prognostic impact of tissue inhibitor of matrix metalloproteinase-I (TIMP-I) in patients with CHF

Solomakhina N. I., Belenkov Y. N.
State Budgetary Educational Institution “I. M. Sechenov First Moscow State Medical University” of the RF Ministry of Health Care, Trubetskaya 8, Bld. 2, Moscow 119991

Keywords: metalloproteinase, prognosis, CHF

DOI: 10.18087/rhfj.2010.5.1405

Background. Increased activity of matrix metalloproteinases is associated with increased risk of cardiovascular events. Objective. To study prognostic role of matrix metalloproteinases I tissue inhibitor (TIMP-I) in patients with CHF. Materials and methods. 47 elderly patients with mostly III and IV CHF FC (NYHA) (mean age 80.0±1.2 years) were followed-up during 3 months. Sex- and age-matched control group included 14 patients without manifestation of CHF. Serum TIMP-I was measured with solid-phase ELISA. Results. During follow-up 16 patients of main- and 3 of control group died. Significant difference in TIMP-I levels between died patients and survivors in study group was observed (876.4±74.6 and 596.7±31.3 ng / ml, p<0.001) as well as in control group (1020.0±144.8 и 614.5±45.9 ng / ml, p<0.001). Thus, since there is low correlation between symptoms and severity of cardiac dysfunction in CHF, measurement of blood biomarkers level can be useful for disease prognosis evaluation.
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Solomakhina N. I., Belenkov Y. N. Prognostic impact of tissue inhibitor of matrix metalloproteinase-I (TIMP-I) in patients with CHF. Russian Heart Failure Journal. 2010;11(5):281-284.

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