Russian Heart Failure Journal 2010year Changes in urine protein profile and progression of chronic heart failure and renal dysfunction
Changes in urine protein profile and progression of chronic heart failure and renal dysfunction
Batyushin M. M., Vrublevskaya N. S., Sarvilina I. V.
Keywords: urine protein profile, prognostics, chronic kidney disease, CHF
Background. Results of clinical study showed that the frequency of renal function decline in patients with CHF can reach 25%. Objective. To study the property of mass-spectral analysis of urine proteins in patients with CHF as a method of renal function estimation and rate of underlying disease progression. Materials and methods. The study included 90 patients with CHF FC II‑IV. Control group included 30 healthy individuals. Differential selection of urine peptides and proteins was performed by mass-spectrometry. Results. In patients with CHF the urine contains proteins, regulating vascular tone and activity of coagulation and anticoagulation systems, not characteristic for urine protein profile of healthy people. In group of patients with CHF vs control group pattern with high expression of metabolic urine proteins was less common. But patients with high expression of transcription factors, regulating cell nucleus, were more common. With increase of CHF FC urine levels of glipican 1, ANP-converting enzyme, prothrombin B-chain significantly increased. At the same time, with progression of underlying disease detectability of urine betaine-homocysteine methyltransferase 2 decreased. Thus the change of urine protein profile in patients with CHF is very important for prediction of prognosis of underlying disease and renal function.
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Batyushin M. M., Vrublevskaya N. S., Sarvilina I. V. Changes in urine protein profile and progression of chronic heart failure and renal dysfunction. Russian Heart Failure Journal. 2010;11(4):227-232.