Russian Heart Failure Journal 2010year Causes and mechanisms of organs remodeling in patients with kidney, cardiovascular diseases and bronchial asthma


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2010/

Causes and mechanisms of organs remodeling in patients with kidney, cardiovascular diseases and bronchial asthma

Pytskiy V. I.
State Budgetary Educational Institution of Higher Professional Education, “N.I. Pirogov Russian National Research Medical University” of the RF Ministry of Health Care, Ostrovityanova 1, Moscow 117997

Keywords: bronchial asthma, kidney, remodeling, cardiovascular system

DOI: 10.18087/rhfj.2010.4.1364

This article discusses mechanisms underlying the remodeling of several organs. The remodeling begins with one common cause – an increased functional load on the organ. Transforming growth factor-β1 plays a central role in remodeling of heart, kidney, respiratory tract. It stimulates collagenoblasts to produce collagen, provides phenotypic transformation of collagenoblasts into myofibroblasts, induces matrix metalloproteinase formation in extracellular matrix and growth of smooth muscle cells. The development of organ fibrosis is reversible. Appropriate treatment can reduce the fibrosis severity.
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Pytskiy V. I. Causes and mechanisms of organs remodeling in patients with kidney, cardiovascular diseases and bronchial asthma. Russian Heart Failure Journal. 2010;11(4):249-254.

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