Russian Heart Failure Journal 2010year Efficacy and safety of intracoronary transplantation of bone marrow mononuclear cells in patients with postinfarction myocardial changes and heart failure
Efficacy and safety of intracoronary transplantation of bone marrow mononuclear cells in patients with postinfarction myocardial changes and heart failure
Bazhan S.S., Sychev A.V., Mareev V.Y., Samko A.N., Stukalova O.V., Saidova M.A., Shitov V.N., Sergienko V.B., Romanov Y.A., Sokolov A.N., Belenkov Y.N.
Keywords: intracoronary transplantation, bone marrow mononuclear cells, postinfarction cardiosclerosis, chronic heart failure
Topicality. Development of strategies for necrotic myocardium regeneration has considerable practical interest. Objective. To study the influence of intracoronary transplantation of bone marrow mononuclear cells (BMMC) on clinical and functional status, parameters of left ventricular remodeling and its safety in patients with postinfarction cardiosclerosis (PICS), and CHF. Materials and methods. In total 24 patients with extensive postinfarction cardiosclerosis, LVEF <40 %, without hemodynamically significant lesion of infarct-unrelated coronary artery (IUA), with comprehensive treatment of CHF, were randomized blindly to stem cell therapy group (n=12) and control (n=12). First group received BMMC intracoronary or to the pool of infarct-related artery (IRA, n=6) or into the pool of IUA (n=6). The control group included patients with revascularized (n=6), and not revascularized IRA (n=6). Follow-up duration was 6 months. At baseline, after 3 and 6 months assessement of clinical and functional status, indicators LV remodeling / perfusion, as well as safety of therapy was performed. Results. Intracoronary transplantation of BMMC in patients with PICS and decreased LV ejection fraction, adequate revascularization and optimally matched treatment, can promote just moderate improvement of LV myocardial contractility without significant reduction of cicatricial lesion zone. This effect is accompanied by significant increase of physical stress tolerance. Further research of efficacy and safety of cell therapy in this group of patients are needed.
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Bazhan S.S., Sychev A.V., Mareev V.Y. et al. Efficacy and safety of intracoronary transplantation of bone marrow mononuclear cells in patients with postinfarction myocardial changes and heart failure. Russian Heart Failure Journal. 2010;11(2):139-147.