Russian Heart Failure Journal 2010year Brain natriuretic peptide and survival of patients on programmed hemodialysis


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Brain natriuretic peptide and survival of patients on programmed hemodialysis

Kharlamova U. V., Iljicheva O. E.

Keywords: survival of patients, brain natriuretic peptide (BNP), programmed hemodialysis

DOI: 10.18087/rhfj.2010.4.1355

Background. The system of natriuretic peptides plays an important role in the pathogenesis of adverse cardiovascular events. Objective. To study the level of brain natriuretic peptide (BNP) and related survival of patients on programmed hemodialysis. Materials and methods. The study included 51 patients with terminal chronic renal failure (CRF) on programmed hemodialysis. The level of BNP, hemoglobin, albumin, calcium, phosphorus, blood preassure, echocardiography, as well as survival were evaluated. Results. In hemodialysis patients the level of BNP does not dependent on gender and causes of CRF. In dead patients BNP level was significantly higher than in survived patient. Increased level of BNP (>100 pg / ml) significantly decreased survival. Thus BNP level is a significant predictor of survival in hemodialysis patients.
  1. Бикбов Б. Т., Томилина Н. А. О состоянии заместительной терапии больных с хронической недостаточностью в Российской Федерации в 2000 г. (Отчет по данным Российского регистра). Нефрология и диализ. 2002;4 (3):148–170.
  2. Levey AS, Eknoyan G. Cardiovascular disease in chronic renal disease. Nephrol Dial Transplant. 1999;14 (4):828–833.
  3. Tsutamoto T, Wada A, Maeda K et al. Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure: prognostic role of plasma brain natriuretic peptide concentration in patients with chronic symptomatic left ventricular dysfunction. Circulation. 1997;96 (2):509–516.
  4. de Lemos JA, Morrow DA, Bentley JH. The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes. N Engl J Med. 2001;345 (14):1014–1021.
  5. Kasap S, Gönenc A, Sener DE, Hisar İ. Serum cardiac markers in patients with acute myocardial infarction: oxidative stress, C-reactive protein and N-terminal probrain natriuretic Peptide. J Clin Biochem Nutr. 2007;41 (1):50–57.
  6. Bibbins-Domingo K, Gupta R, Na B et al. N-terminal fragment of the prohor­mone brain-type natriuretic peptide (NT-proBNP), cardiovascular events, and mortality in patients with stable coronary heart disease. JAMA. 2007;297 (2):169–176.
  7. Vanderheyden M, Bartunek J, Goethals M. Brain and other natriuretic peptides: molecular aspects. Eur J Heart Fail. 2004;6 (3):261–268.
  8. Агеев Ф. Т., Овчинников А. Г. Мозговой натрийуретический гормон и дисфункция левого желудочка. Журнал Сердечная Недостаточность. 2009;10 (5):271–281.
  9. Galasko G, Lahiri A, Barnes S et al. What is the normal range for N-terminal pro-brain natriuretic peptide? How well does this normal range screen for cardiovascular disease? Eur Hart J. 2005;26 (21):2269–2276.
  10. Yoshimura M, Yasue H, Okumura K et al. Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure. Circulation. 1993;87 (2):464–469.
  11. Bay M, Kirk V, Parner J et al. NT-proBNP: a new diagnostic screening tool to differentiate between patients with normal and reduced left ventricular systolic function. Heart. 2003;89 (2):150–154.
  12. Dokainish H, Zoghbi WA, Lakkis NM et al. Incremental predictive power of B-type natriuretic peptide and tissue Doppler echocardiography in the prognosis of patients with congestive heart failure. J Am Coll Cardiol. 2005;45 (8):1223–1226.
  13. Clerico A, Iervasi G, Mariani G. Pathophysiologic relevance of measuring the plasma levels of cardiac natriuretic peptide honnones in hymans. Horm Metab Res. 1999;31 (9):487–498.
  14. Wang TJ, Larson MG, Levy D. Plasma natriuretic peptide levels and the risk of cardiovascular events and death. N Engl J Med. 2004 12;350 (7):655–663.
  15. Latini R, Masson S, Wong M et al. Incremental prognostic value of changes in B-type natriuretic peptide in heart failure. Am J Med. 2006;119 (1):70.e23–30.
Kharlamova U. V., Iljicheva O. E. Brain natriuretic peptide and survival of patients on programmed hemodialysis. Russian Heart Failure Journal. 2010;11(4):233-235.

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