Russian Heart Failure Journal 2010year Opportunities for application of various doses of coenzyme Q10 in patients with chronic heart failure


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2010/

Opportunities for application of various doses of coenzyme Q10 in patients with chronic heart failure

Sizova J. M., Farafonova T. N., Medvedev O. S., Kalenikova E. I., Korotaeva A. L.

Keywords: quantitative analysis, coenzyme Q10, CHF

DOI: 10.18087/rhfj.2010.4.1351

Background. One of possible ways of influence on symptoms and quality of life in patients with CHF is to correct existing disorders of myocardial metabolism. Coenzyme Q10 (CoQ10) is a promising drug. Objective. To determine optimal dose of CoQ10 for treatment of patients with CHF receiving standard therapy. Materials and methods. The study included 24 patients with CHF FC II-III (16 men and 8 women, average age 62 years), complicating the course of CAD. All patients were divided into 3 groups: first group additionally to standard therapy received CoQ10, 60 mg (2 ml of "Qudesan"), 2nd group – CoQ10, 90 mg (3 ml of "Qudesan"), 3d group – CoQ10, 120 mg (4 ml of "Qudesan"). Follow-up lasted for 4 weeks. Efficacy and tolerability were evaluated by dynamics of clinical manifestations of CHF, CHF FC, exercise tolerance, 6 min walk test. CoQ10 plasma level was measured by high performance liquid chromatography with electrochemical detection. Results. Wide variation of CoQ10 initial concentration (from 183 to 913 ng/ml, on average – 489 ng/ml) was observed in patients with CHF. Evaluation of dynamics of CoQ10 plasma level showed that there was significant increase of CoQ10 blood level in all 3 groups of patients with CHF treated with different doses. Regardless of the dose (60, 90 or 120 mg/day), magnification of CoQ10 plasma level was about the same: 2.3 in patients receiving 60 mg/day, 2.4 in patients receiving 90 and 120 mg/day. Thus, CoQ10 60–120 mg a day (which corresponds to 2.4 ml of study drug) within 4 weeks leads to a significant increase of CoQ10 plasma level. No significant difference in dynamics of CoQ10 level depending on the drug’s dose was revealed. The optimal dose of CoQ10 in combined pharmacotherapy in patients with CHF is 60 mg a day. Adding CoQ10 to standard therapy in patients with CHF results in increased exercise tolerance according to 6 min walk test, improved general health, reduced dyspnea and heart pain.
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Sizova J. M., Farafonova T. N., Medvedev O. S. et al. Opportunities for application of various doses of coenzyme Q10 in patients with chronic heart failure. Russian Heart Failure Journal. 2010;11(4):218-222.

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