Russian Heart Failure Journal 2010year Relationship of angiotensinogen gene M235T polymorphism with clinical and functional characteristics and 5-year forecast in patients with ischemic chronic heart failure

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Relationship of angiotensinogen gene M235T polymorphism with clinical and functional characteristics and 5-year forecast in patients with ischemic chronic heart failure

Krasnova O. A., Ivanov S. G., Sitnikova M. Y.
Federal State Budgetary Institution, “North-West Federal Medical Research Center” of the RF Ministry of Health Care, Akkuratova 2, St.-Petersburg 197341

Keywords: angiotensinogen gene polymorphism, chronic heart failure, myocardial remodeling, mortality

DOI: 10.18087/ rhfj.2010.3.1342

Topicality. Angiotensinogen (AGT) gene polymorphism is one of the most studied topics in the area of cardiovascular diseases. There is no consensus on the impact of this polymorphism on disease flow and prognosis of patients with CHF. Objective. To identify the relationship between AGT gene M235T polymorphism and clinical, structural and functional characteristics and prognosis of patients with CHF. Materials and methods. The study included 105 men, residents of St. Petersburg, aged 59–78 years with ischemic CHF, LVEF <45 %. All patients underwent comprehensive clinical, laboratory and instrumental examination. Results. Patients with T-allele had MI at a younger age than patients with MM-genotype (p<0,05). Significantly larger LV size and mean pulmonary artery pressure were revealed in patients with M-allele. Patients with MM-genotype had ventricular arrhythmias of higher grade than patients with TT-genotype (p=0,004). 39 % of patients with CHF died during 5‑year follow-up, there was predominance of M-allele in comparison with group of survivors. Thus, the genotype distribution of AGT gene M235T polymorphism of studied sample of patients with CHF, is consistent with its distribution in European population. There was no relationship between AGT gene polymorphism and presence of risk factors for systolic ischemic CHF, but there was the association between TT-genotype and earlier debut of MI (vs patients with M-allele). Large LV size and high grade ventricular arrhythmias were reported for patients with M-alleles in comparison with T-allele patients, despite the equal duration and severity of CHF. Patients with systolic CHF who died within 5 years of follow-up, were characterized by predominance of M-allele.
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Krasnova O. A., Ivanov S. G., Sitnikova M. Y. Relationship of angiotensinogen gene M235T polymorphism with clinical and functional characteristics and 5-year forecast in patients with ischemic chronic heart failure. Russian Heart Failure Journal. 2010;11(3):153-156.

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