Russian Heart Failure Journal 2010year Study of growth factor receptors expression and troponin C in patients with heart failure
Study of growth factor receptors expression and troponin C in patients with heart failure
Pushkareva A. E., Enikeeva G. R., Kuchina T. A., Khusainova R. I., Valiev R. R., Shumkin A. M.
Keywords: myocardial remodeling, receptors, heart failure, troponin C, growth factors
Actuality. Heart remodeling in patients with HF is mediated by neurohormones and biologically active substances including cytokines and growth factors. Influence of growth mediators on molecular-cellular mechanisms of myocardial remodeling remains unclear. Aim. To study the expression of receptor type 1 of transforming growth factor β (TGF-β), receptor type 3 of vascular endothelial growth factor and troponin C in myocardial remodeling. Materials and methods. The study was conducted on 101 samples of autopsy material of patients with heart failure. Immunohistochemical study was performed using monoclonal antibodies, afinne contacting with receptors for vascular endothelial growth factor (VEGF R3), with receptors for transforming growth factor (TGF-β R1) and troponin C. Results. A significant increase of TGF-β R1 expression was revealed in hypertensive patients with LV hypertrophy (LVH) in comparison with control (p<0.00275). Statistically significant positive correlation was detected between TGF-β R1 expression and cardiomyocyte hypertrophy in hypertensive patients with LVH. The same correlation was determined in patients with dilated cardiomyopathy. In patients with coronary artery disease TGF-β R1 expression was significantly correlated with LV myocardium thickness in contrast to control.
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Pushkareva A. E., Enikeeva G. R., Kuchina T. A. et al. Study of growth factor receptors expression and troponin C in patients with heart failure. Russian Heart Failure Journal. 2010;11(2):92-96.