Russian Heart Failure Journal 2010year Study of growth factor receptors expression and troponin C in patients with heart failure

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Study of growth factor receptors expression and troponin C in patients with heart failure

Pushkareva A. E., Enikeeva G. R., Kuchina T. A., Khusainova R. I., Valiev R. R., Shumkin A. M.

Keywords: myocardial remodeling, receptors, heart failure, troponin C, growth factors

DOI: 10.18087/rhfj.2010.2.1321

Actuality. Heart remodeling in patients with HF is mediated by neurohormones and biologically active substances including cytokines and growth factors. Influence of growth mediators on molecular-cellular mechanisms of myocardial remodeling remains unclear. Aim. To study the expression of receptor type 1 of transforming growth factor β (TGF-β), receptor type 3 of vascular endothelial growth factor and troponin C in myocardial remodeling. Materials and methods. The study was conducted on 101 samples of autopsy material of patients with heart failure. Immunohistochemical study was performed using monoclonal antibodies, afinne contacting with receptors for vascular endothelial growth factor (VEGF R3), with receptors for transforming growth factor (TGF-β R1) and troponin C. Results. A significant increase of TGF-β R1 expression was revealed in hypertensive patients with LV hypertrophy (LVH) in comparison with control (p<0.00275). Statistically significant positive correlation was detected between TGF-β R1 expression and cardiomyocyte hypertrophy in hypertensive patients with LVH. The same correlation was determined in patients with dilated cardiomyopathy. In patients with coronary artery disease TGF-β R1 expression was significantly correlated with LV myocardium thickness in contrast to control.
  1. American Heart Association. Heart disease and Stroke Statistics – 2003. National Center, 7272 Greenville Avenue, Dallas, Texas, 2003.
  2. Weber KT. Cardioreparation in hypertensive heart disease. Hypertension. 2001;38 (3 Pt 2):588–591.
  3. Cohn JN, Ferrari R, Sharpe N, on Behalf of an International Forum on Cardiac Remodeling. Cardiac remodeling-concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. J Am Coll Cardiol. 2000;35 (3):569–582.
  4. Weber K. T. Targeting pathological remodeling: concepts of cardioprotection and reparation. Circulation. 2000;102 (12):1342–1345.
  5. Rosenkranz S. TGF-beta1 and angiotensin networking in cardiac remodeling. Cardiovasc Res. 2004;63 (3):423–432.
  6. Hein S, Arnon E, Kostin S et al. Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation. 2003;107 (7):984–991.
  7. Xiao H, Zhang YY. Understanding the role of transforming growth factor-beta signaling in the heart: overview of studies using genetic mouse models. Clin Exp Pharmacol Physiol. 2008;35 (3):335–341.
  8. Schultz Jel J, Witt SA, Glascock BJ et al. TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II. J Clin Invest. 2002;109 (6):787–796.
  9. Лушникова Е. К., Непомнящих А., Розенберг М. А. Морфогенетические основы дилатационной кардиомиопатии. – М.: Медицина, 2004. – 204 с.
  10. Моисеев В. С. Сердечная недостаточность и достижения генетики. Сердечная недостаточность 2000; (1) 4:121–130.
  11. Katz AM, Konstam MA. Heart Failure, Pathophysiology, Molecular Biology and Clinical Management. 2nd ed. Philadelphia, PA: Lippincott, Williams and Wilkins; 2008:143–149.
  12. Khan R, Sheppard R. Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia. Immunology. 2006;118 (1):10–24.
  13. Li G, Borger MA, Williams WG et al. Regional overpression of insulin-like growth factor and transforming growth factor in the myocardium of patient with hypertrophic obstructive cardiomyopathy. J Thorac Cardiovasc Surg. 2002;123 (1):89–95.
  14. Li G, Li RK, Mickle DA et аl. Elevated insulin-like growth factor-I and transforming growth factor-beta 1 and their receptors in patients with idiopathic hypertrophic obstructive cardiomyopathy. A possible mechanism. Circulation. 1998;98 (19 Suppl):II144–149.
  15. Jiang X, Zeng HS, Guo Y et al. The expression of matrix metalloproteinases-9, transforming growth factor-beta1 and transforming growth factor-beta receptor I in human atherosclerotic plaque and their relationship with plaque stability. Chin Med J (Engl). 2004;117 (12):1825–1829.
  16. Jachec W, Foremny A, Domal-Kwiatkowska D et al. Expression of TGF-beta1 and its receptor genes (TbetaR I, TbetaR II, and TbetaR III-betaglycan) in peripheral blood leucocytes in patients with idiopathic pulmonary arterial hypertension and Eisenmenger’s syndrome. Int J Mol Med. 2008;21 (1):99–107.
  17. Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med. 2003;9 (6):677–684.
  18. Brian H, Annex MD. Therapeutic angiogenesis: a treatment for the New Millenium or passing fad? Сardiology Rounds. 2002;6 (1):1–6.
  19. Lohela M, Saaristo A, Veikkola T, Alitalo K. Lymphangiogenic growth factors, receptors and therapies. Thromb Haemost. 2003;90 (2):167–184.
Pushkareva A. E., Enikeeva G. R., Kuchina T. A. et al. Study of growth factor receptors expression and troponin C in patients with heart failure. Russian Heart Failure Journal. 2010;11(2):92-96.

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