Russian Heart Failure Journal 2010year Metabolic disorders and endothelial function in different age groups of patients with diastolic CHF


To access this material please log in or register

Register Authorize
2010/

Metabolic disorders and endothelial function in different age groups of patients with diastolic CHF

Sukmanova I. A., Yakhontov D. A., Pospelova T. I.

Keywords: diastolic dysfunction, metabolic disorders, different age groups, endothelial function, CHF

DOI: 10.18087/rhfj.2010.2.1314

Actuality. In elderly and senile patients the role of diastolic dysfunction in the pathogenesis of CHF increases. Aim. To study metabolic parameters and markers of endothelial function in patients with diastolic CHF in different age groups. Materials and methods. 146 men with chronic heart failure and diastolic dysfunction were divided into two groups depending on age. The first group included 69 men aged 31-55 years with FC II-III CHF, NYHA, I and IIA stages (Strazhesko-Vasilenko classification). The second group included 77 patients aged 62-72 years with FC II-III CHF, NYHA, I, IIA and IIB stages. The control included 30 healthy volunteers. Carbohydrate metabolism was assessed by the level of glycated hemoglobin (HbA 1C). In all patients HOMA index was calculated, measurment of NT-proBNP, proinflammatory (IL-1β, TNF-α) and antiinflammatory (IL-4) cytokines were performed. Results. Significant metabolic changes in patients with diastolic CHF were detected regardless of age. But patients of average age had more significant changes of carbohydrate metabolism. Endothelial dysfunction was detected in all patients, but in elderly patients NO-producing endothelial function disorders were detected more often.
  1. Ольбинская Л. И., Игнатенко С. Б. Патогенез и современная фармакотерапия хронической сердечной недостаточности. Журнал Сердечная недостаточность. 2002;3 (2):87–91.
  2. Packer M. The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure. J Am Coll Cardiol. 1992;20 (1):248–254.
  3. Коркушко О. В. Клиническая кардиология в гериатрии. – М.: "Медицина", 1980. – 234 с.
  4. Елисеев О. М. Натрийуретические пептиды. Эволюция знаний. Журнал Терапевтический архив. 2003;75 (9):40–45.
  5. Андреев Д. А., Батищев П. Н. Некоторые аспекты практического использования мозгового натрийуретического пептида в диагностических целях. Бюллютень НЦССХ им А. Н. Бакулева РАМН. 2004;3:146–155.
  6. Melo LG, Pang SC, Ackermann U. Atrial natriuretic peptide: regulator of chronic arterial blood pressure. News Physiol Sci. 2000;15:143–149.
  7. McDonagh TA, Cunningham AD, Morrison CE et al. Left ventricular dysfunction, natriuretic peptides, and mortality in an urban population. Heart. 2001;86 (l): 21–26.
  8. Dahlstrom U. Can natriuretic peptides be used for the diagnosis of diastolic heart failure? Eur J Heart Fail. 2004;6 (3):281–287.
  9. Скворцов А. А., Челмакина С. А., Пожарская Н. И. и др. Модулирование активности системы нейрогуморальной регуляции при хронической сердечной недостаточности. РМЖ. 2000;8 (2):87–93.
  10. Кузнецов Г. Э. Оценка функции левого желудочка с позиции изменения его геометрии у больных сердечной недостаточностью на фоне ишемической болезни сердца. Журнал Сердечная недостаточность. 2002;3 (6):292–294.
  11. Зимин Ю. В. Происхождение, диагностическая концепция и клиническое значение синдрома инсулинорезистентности или метаболического синдрома Х. Кардиология. 1998;38 (6):71–81.
  12. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002;287 (3):356–359.
  13. Шестакова М. В. Дисфункция эндотелия – причина или следствие метаболического синдрома? Русский медицинский журнал. 2001;9 (2):88–93.
  14. Cleland JG, Clark A. Has the survival of the heart failure population changed? Lessons from trials. Am J Cardiol. 1999;83 (5B):112D-119D.
  15. Festa A, D'Agostino R Jr, Howard G et al. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation. 2000;102 (1):42–47.
Sukmanova I. A., Yakhontov D. A., Pospelova T. I. Metabolic disorders and endothelial function in different age groups of patients with diastolic CHF. Russian Heart Failure Journal. 2010;11(2):116-119.

To access this material please log in or register

Register Authorize
Ru En