Russian Heart Failure Journal 2009year Left ventricular myocardial hypertrophy and its predictive significance in patients with CRD


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2009/

Left ventricular myocardial hypertrophy and its predictive significance in patients with CRD

Gendlin G. E., Shilo V. Yu., Tomilina N. A., Storozhakov G. I., Borisovskaya S. V., Ettinger O. A., Badaeva S. V., Gavryushina O. A.

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Urgency. A tight association between left ventricular hypertrophy (LVH) and death rate including death from cardiovascular complications has been demonstrated in the population of patients receiving the programmed hemodialysis treatment (PHD). Aim. Evaluating the prognostic significance of LVH in patients treated with programmed hemodialysis. Materials and methods. We have observed 212 patients receiving the PHD treatment. EchoCG was performed in 185 patients (89 women and 96 men; median age, 50 years) at the study onset. Among other echoCG parameters, the LV myocardial mass index (MMI) was calculated, and the ejection fraction was measured. Pulse wave velocity (PWV) was measured in the aorta. Biochemical and clinical blood tests were performed. A 2-day study of BP dynamics was performed in 86 patients (43 men and 43 women) in the interdialysis period. In addition, 78 patients (31 men and 47 women younger than 55 years) with predialysis renal insufficiency were examined as a reference group, in accordance with the same schedule. Results. It was shown that LVH determined survival of patients receiving the replacement renal therapy with PHD, especially in the female population. Death of the evaluated women was caused by conditions associated with LVH, primarily heart failure. Death of female patients with predialysis chronic renal disease receiving the PHD treatment was caused by a combination of high BP and some uremia factors, correction of which may improve survival of such patients.
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