Russian Heart Failure Journal 2009year The use of ACEI in patients with CHF of ischemic genesis
The use of ACEI in patients with CHF of ischemic genesis
Drapkina O. M., Dikur O. N.
ACE inhibitors have long proven effective antihypertensive drugs. In recent decade, indications to using these drugs in patients with cardiovascular diseases, primarily CHF, have been tended to expansion. IHD with its most dramatic part, MI, has the biggest share in CHF genesis. Efficacy of ACEI in the treatment of IHD has been demonstrated in many international randomized studies. Potential beneficial effects of ACEI in IHD include restriction of LV and vascular wall media hypertrophy, improvement of endothelial function with resulting slowing of atherosclerosis progression, stabilization of atherosclerotic plaques and reduced risk for thrombosis. Review attempts to analyze possibilities of using ACEI in patients with IHD. Based on available data ramipril and perindopril are drugs of choice for multimodality therapy in patients with IHD
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