Russian Heart Failure Journal 2009year Metabolic parameters, markers of endothelial function and oxidative stress in geriatric patients with systolic and diastolic CHF


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2009/

Metabolic parameters, markers of endothelial function and oxidative stress in geriatric patients with systolic and diastolic CHF

Sukmanova I. A., Yakhontov D. A.

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Urgency. Effects of age-related peculiarities of the cardiovascular system on key steps of the pathogenesis, course and prognosis of systolic and diastolic CHF are presently not studied sufficiently. Aim. To study parameters of carbohydrate, lipid and purine metabolism, major markers of endothelial function and oxidative stress and their interrelation with morpho-functional parameters of the heart in elderly patients with different types of CHF. Materials and methods. Study enrolled 127 men aged 60–75 years (mean age 67.4 ±0.3 years) assigned to 2 groups. Group 1 included 77 patients with diastolic CHF; group 2 consisted of 50 patients with systolic CHF. Control group included 30 healthy volunteers. Levels of pro- (IL-1β, TNF-α) and anti-inflammatory (IL-4) cytokines, the BNP fragment of brain natriuretic peptide (BNP), nitric oxide (NO), and markers of lipid peroxidation (LP) were measured. Results. Patients with both systolic and diastolic CHF had serious metabolic alterations, significant disorders of endothelial function and activation of oxidative stress markers. The observed disorders were aggravated by age-related changes in the cardiovascular system, which worsened both the course of disease and subsequent prognosis. Significantly higher levels of TNF-α, BNP fragment of BNP and uric acid in the group with systolic CHF indicated more severe disease and unfavorable prognosis in this category of patients.
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