Russian Heart Failure Journal 2008year Possibilities of using omega-3 polyinsaturated fatty acids for secondary prevention in patients with heart failure of ischemic etiology. Design of study «ONICS»

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Possibilities of using omega-3 polyinsaturated fatty acids for secondary prevention in patients with heart failure of ischemic etiology. Design of study «ONICS»

Arbolishvili G.N., Mareev V.Yu.



Increased risk of sudden death (SD) is the major factor which compromises the prognosis in patients with MI. In recent decades much progress has been achieved in prevention of SD due to the use of implantable cardioverter defibrillators (ICD). These devices provide reduction in the risk of all-cause mortality by 30% in patients with postinfarction cardiosclerosis and pronounced systolic dysfunction. However the use of ICD in routine clinical practice is limited because of very high cost of this treatment while antiarrhythmics are much less effective and have substantial restrictions. Formulations of concentrated and highly purified ω-3 polyunsaturated fatty acids (PUFA) are a treatment which in combination with standard optimal therapy would reduce the risk of SD. The present review analyzes the effect of PUFA on SD rate in patients with IM and CHF and their role in secondary prevention of IHD.
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