Russian Heart Failure Journal 2008year Pre- and postconditioning as methods of cardioprotection: pathophysiological and clinical aspects


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2008/

Pre- and postconditioning as methods of cardioprotection: pathophysiological and clinical aspects

Shlyuakhto E. V., Nifontov E. M., Galagudza M. M.

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A major statement of the concept for cardioprotection proposed in mid-70s is a possibility to restrict irreversible ischemic and reperfusion myocardial injury using various interventions. Due to experimental studies performed in recent decade the arsenal of cardioprotective treatments has been substantially expanded. Specifically, it was shown that the endogenous cardioprotective phenotype can be induced by a broad spectrum of factors influencing the heart or the body as a whole before occurrence of ischemia (myocardial preconditioning). On the other hand, it appeared that interrupting the early reperfusion period with several brief ischemia episodes resulted in a considerable attenuation of reperfusion injury (postconditioning). Review considers mechanisms underlying pre- and postconditioning and also prospects of their practical application in patients with IHD.
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