Russian Heart Failure Journal 2008year Role of renin-angiotensin axis genes in development of chronic heart failure in individuals with familial arterial hypertension, native residents of the Mordovia Republic


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Role of renin-angiotensin axis genes in development of chronic heart failure in individuals with familial arterial hypertension, native residents of the Mordovia Republic

Goncharova L. N., Birlyukova D. V., Khasanova Z. B., Timoshkina E. I., Semenova S. V., Fedotkina L. K., Kuzovenkova O. N., Snegovskoy V. A., Konovalova N. V., Postnov A. Yu.

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Urgency. Studying genetic factors involved in progression of CHF is critical for detection and treatment of this disease representing a global problem of current cardiology. Aim. Studying the role of ACE and AGT2R1 gene polymorphism in development and progression of CHF in Mordvinian and Russian patients with familial AH. Materials and methods. 153 patients (73 Russians, 80 Mordvinians) were evaluated. All patients underwent a comprehensive clinical and instrumental examination. CHF FC was determined using a 6-min walking test in all patients. The instrumental examination included 12-lead EGC and echoCG. Polymorphism markers were assayed by PCR and RFLP-analysis using respective primers. Results. The DD genotype of the ACE gene I/D polymorphism marker was associated with more severe disease (FC III-IV) in Mordvinian patients. Present study did not reveal any difference in incidence of АА, АС and СС genotypes, A and C alleles of AGT2R1 gene in patient groups independent on CHF FC.
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