Russian Heart Failure Journal 2008year Genetic determinancy of inflammation in atherosclerotic damage of cardiac vasculature

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Genetic determinancy of inflammation in atherosclerotic damage of cardiac vasculature

Orlova N.V.



Urgency. Prevalence of CVD and related disability and mortality warrant continued study of pathogenetic mechanisms for development of this pathology. Aim. Revealing the interrelation between inflammatory indices and severity of coronary atherosclerotic lesions and their dependence on IL-10 and TNF-α gene polymorphism. Materials and methods. 160 patients with IHD were evaluated. Coronary angiography was performed; haptoglobin, С-reactive protein (CRP), α1-antitrypsin, orsomucoid, complement С3 component, ceruloplasmin, TNF-α, INF-γ, I–L4, IL-6, IL-8 and IL-10 levels were measured; and TNF-α and IL-10 gene polymorphism was determined. Results. We revealed an interrelation between coronary artery lesions and severity of inflammation markers and inflammation gene polymorphism. Therefore the inflammatory mechanism of coronary artery lesions may be genetically predefined.
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