Russian Heart Failure Journal 2008year Parameters of endothelial vasoregulatory function in patients with metabolic syndrome

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Parameters of endothelial vasoregulatory function in patients with metabolic syndrome

Mkrtumyan A. M., Biryukova E. V., Markina N. V.



Urgency. Endothelial dysfunction is a marker of metabolic and vascular disorders. However studies of endothelial function in patients with metabolic syndrome (MS) are at initial steps. Aim. Studying parameters of endothelial function in patients with MS and determining the interrelation of endothelial dysfunction (ED) and major components of the syndrome. Materials and methods. 104 patients with MS were included in the study; 35 subjects without apparent disease made up a control group. Levels of glucose, immunoreactive insulin (IRI), TNF-α, endothelin-1 and NO metabolites in blood were measured in the fasting condition and after the oral glucose tolerance test (OGTT). Results. The MS was associated with pronounced ED. The glucose test resulted in decreased release of the vasodilatory factor, NO and increased level of the vasoconstrictory factor endothelin-1, in patients with MS. Levels of NO and endothelin-1 positively correlated with levels of the major markers for insulin resistance (hyperinsulinemia, HOMA index) and TNF-α in patients with MS.
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