Russian Heart Failure Journal 2007year Effect of ultra-low dose antibody to angiotensin II A1 receptor C-terminal fragment (Cardos) on the course of chronic heart failure: Results of the first clinical trial


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2007/

Effect of ultra-low dose antibody to angiotensin II A1 receptor C-terminal fragment (Cardos) on the course of chronic heart failure: Results of the first clinical trial

Petrov V. I., Ivanenko V. V., Davydova N. A., Epshtein O. I., Sergeeva S. A., Kachanova M. V., Chepurina N. G., Lopatin Yu. M.

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Urgency. Optimization of therapy for CHF is one of the most important issues in cardiology. The use of drugs modulating the enhanced activity of neuro-hormonal systems underlies current treatment of patients with CHF. Search for new efficient and safe medicines for treatment of CHF is continuing. Aim. Studying the effect of a preparation of antibody to the AII AT1 receptor C-terminal fragment (Cardos) as a part of combination therapy on the clinical state, cardiovascular remodeling and exercise tolerance in patients with CHF. Material and methods. This randomized, single-blinded, placebo-controlled study included 60 patients with II–IV FC CHF, LV EF≤40%. Patients were evaluated prior to the study onset and at 6 months. Evaluation included assessment of clinical state, quality of life, morpho-functional parameters of the heart, exercise tolerance and laboratory tests. Results. Study demonstrated a beneficial effect of long-term treatment with Cardos as a part of combination therapy on the course of CHF; at 6 months of follow-up, CHF FC significantly decreased by 17.3%, LV EF increased by 24%, and the 6-min walk distance increased by 10.8%.

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