Russian Heart Failure Journal 2007year Primary prevention of CHF in patients with AH using ACE inhibitors


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2007/

Primary prevention of CHF in patients with AH using ACE inhibitors

Silakova V. N., Smolenskaya O. G. Kamelskikh K. A.

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Urgency. Prevention of progressive LV myocardial hypertrophy is a major challenge of current hypertensiology. Aim. Revealing peculiarities in effects of hydrophilic and lipophilic ACEI on LV remodeling processes and exercise tolerance in the conditions of achieved target BP values. Materials and methods. 79 male patients with I degree AH and vascular risk 1–3 were evaluated. Patients were randomized to two groups. Patients of the first group received lisinopril in a mean dose of 11 ± 3.04 mg / day, and patients of the second group received fosinopril in a mean dose of 12.82 ± 4.41 mg / day. In the course of treatment hydrochlorothiazide was added to ACEI to achieve target BP values. Duration of treatment was 24 weeks. Time course of echoCG parameters was studied, and a bicycle exercise test (BET) was performed. Results. Monopril and diroton effectively reduced BP in patients with AH. After achieving target BP values, the cardioprotective effect of ACEI became different. Monopril more efficiently than diroton normalized the daily profile of BP, enhanced exercise tolerance and inhibited processes of LV remodeling.

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