Russian Heart Failure Journal 2007year Clinical efficacy of the nutritive mixture Peptamen in patientS with III–IV NYHA FC chronic heArT failURe and sigNs of hypotrophy (SATURN-II): preliminary data
Clinical efficacy of the nutritive mixture Peptamen in patientS with III–IV NYHA FC chronic heArT failURe and sigNs
of hypotrophy (SATURN-II): preliminary data
Arutyunov G. P., Kostyukevich O. I., Zvonova E. V., Topilskaya N. V.
Urgency. The completed study SATURN has demonstrated a high prevalence of malnutrition in therapeutic patients. Aim. The study SATURN-II will be designed for evaluating the efficacy of nutritive support in patients with CHF with signs of hypotrophy of different degree. Materials and methods. Study will enroll 576 patients at 12 centers which have participated in study SATURN-I. By the present, 176 patients with CHF and hypotrophy of different degree are enrolled at 9 centers. Patients are randomized to three groups based on the degree of hypotrophy. The method of randomization determines the regimen of therapy (with or without nutritive support) for each group. Parameters of 6-min test, dynamics of lean body weight (LBW), number of hospitalizations and fatal outcomes were evaluated after 8 weeks. Results. Parameters of the 6-min test were higher in subgroups of patients receiving the nutritive support with the nutritive mixture Peptamen than in subgroups of patients receiving only a conventional treatment. Thus, the mean 6-min walk distance increased by 31.5% in patients with III degree hypotrophy receiving the nutritive support and only by 4.5% in patients receiving the conventional therapy. The mean LBW increased by 1.7 ± 0.17 kg and 1.1 ± 0.08 kg, respectively. We can conclude already at this step of study that the nutritive support is effective in patients with CHF providing increases in LBW and exercise tolerance.