Russian Heart Failure Journal 2007year Chronic heart failure in patients with arterial hypertension and polymorphisms of endothelial NO synthase Glu298Asp gene and NAGPH oxidase С242Тp22phox gene


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2007/

Chronic heart failure in patients with arterial hypertension and polymorphisms of endothelial NO synthase Glu298Asp gene and NAGPH oxidase С242Тp22phox gene

Kuznetsova T. Yu., Dudanov I. P., Gavrilov D. V., Parfenova E. V., Samokhodskaya L. M., Balatsky A. V., Makarevich P. I.

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Urgency. Studying the contribution of genetic factors to development of CHF in AH is of interest. Aim. Evaluating incidence of CHF in AH and dependence of CHF on peculiarities of AH course, other RF and endothelial NO synthase Glu298Asp gene and NADPH oxidase С242Тp22phox gene polymorphisms. Materials and methods. 272 male patients with AH (mean age 50.7 years) were evaluated. Control group included 102 subjects (no AH, no CHF). Endothelial NO synthase Glu298Asp and NADPH oxidase gene polymorphisms were determined using the polymerase chain reaction (PCR) and the restrictase method. Results. CHF was diagnosed in 74 (27.2 %) patients. The CHF incidence in patient subgroups based on AH degree was 22 % in I degree AH, 32 % in II degree AH, and 43 % in III degree AH. CHF was observed in 38 % of patients with AH duration of more than 10 years and in 22 % of patients with AH duration of less than 10 years (р=0.005). The CHF incidence was significantly higher in the subgroup of patients with DM (77 % vs. 24 %, р<0.0001), slightly higher in patients with obesity (32 % vs. 25 %, p=0.25), and considerably higher in LV hypertrophy (LVH) (39 % vs. 14 %, p<0.0001). In analysis of endothelial NO synthase Glu298Asp gene polymorphism, genotypes were distributed as follows: GG 58.8 %, GA 32.3 %, АA 8.9 % in AH; GG 53 %, GA 36 %, AA 11 % in control group. In analysis of NADPH oxidase С242Тp22phox gene polymorphism, genotypes were distributed as follows: СС 48.2 %, СТ 44.9 %, ТТ 6.9 % in patients with AH, and СС 42 %, СТ 54 %, ТТ 4 % in the control group. In the subgroup of patients with CHF, genotypes were distributed as follows: GG 64 %, GA 31 %, AA 5 % и СС 50 %, СТ 43 %, and ТТ 7 %.

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