Russian Heart Failure Journal 2006year Effects of perindopril and trimetasidine on the oxidative stress status during the treatment of chronic heart failure in patients after myocardial infarction


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2006/

Effects of perindopril and trimetasidine on the oxidative stress status during the treatment of chronic heart failure in patients after myocardial infarction

Shchukin Yu.V., Seleznev E.I., Davydkin I.L., Djyachkov V.A., Danilova O.E., Novitskaya E.A.

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Urgency. Systemic inta– and extracellular oxidative stress is one of pathogenetic factors in CHF. Aim. Effects of perindopril and trimetasidine on parameters of free radical metabolism in plasma and red cells were studied during the treatment of patients with CHF after MI. Material and methods. 45 male patients aged 38–62 years who had had Q–wave MI 2–5 years ago, were evaluated. All patients had IIA stage III FC CHF. Patients were divided into 2 equivalent groups and received perindopril 8 mg/day as a basis therapy. Patients of group 2 additionally received trimetasidine 70 mg/day. Therapy efficacy was evaluated after 16 weeks of treatment. Control group was age–matched and consisted of 56 men without apparent disease. Free radical metabolism was studied in plasma and red cells. Results. It was found that trimetasidine re–activated plasma gutathione peroxidase and to a lesser extent cytosol superoxide dismutase in the structure of antioxidant enzymes. The antioxidant effect of perindopril occurred primarily at the cell level due to the increased activity of glutathione system components.

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