Russian Heart Failure Journal 2006year Effect of bisoprolol on geometric remodeling and structural and functional activity of myocardium in patients with arterial hypertension


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2006/

Effect of bisoprolol on geometric remodeling and structural and functional activity of myocardium in patients with arterial hypertension

Khozyainova N.Yu., Tsareva V.M., Milyagin V.A., Milyagina I.V.

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Aim. Studying the effect of β-blocker bisoprolol (Concor, «Nycomed») on remodeling, diastolic filling of both ventricles, myocardial ectopic activity, and heart rhythm variability in patients with AH. Materials and methods. Forty-six patients with degree 1–2 AH were evaluated. EchoCG, Holter ECG monitoring and 24-hour BP monitoring were conducted. Results. In patients with AH, bisoprolol slowed progression of cardiovascular remodeling, normalized structural and geometric parameters of the heart and ventricular diastolic filling, reduced autonomic sympathetic tone and ectopic activity of the myocardium, and thereby reduced the risk of sudden arrhythmic death.

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