Russian Heart Failure Journal 2006year PROphylaxis in patients with chronic heart failure againST thrOmbotic complications in Russia (PROSTOR). Study of Clexane efficacy as an additional treatment to the standard therapy in patients with chronic heart failure in hospital setting


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2006/

PROphylaxis in patients with chronic heart failure againST thrOmbotic complications in Russia (PROSTOR). Study of Clexane efficacy as an additional treatment to the standard therapy in patients with chronic heart failure in hospital setting

Mareev V.Yu.

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Urgency. Thromboembolic complications occupy an important place in the structure of CHF morbidity and mortality. However adequate prevention of thromboembolic complications of CHF is far from always performed. Aim. Studying efficacy and safety of the low-molecular weight heparin enoxaparin (Clexane) administered as an additional treatment to the standard therapy in hospitalized CHF patients for prevention
of thromboembolic complications; evaluating the incidence of thromboembolic complications in all admitted patients with CHF. Мaterial and methods. PROSTOR is an open, randomized, comparative, prospective, two-arm, parallel study on patients with CHF and thromboembolism risk, which was performed at 18 centers from January to July, 2004. Thestudyenrolled351patients(177patients,controlgroup; 174 patients, Clexane group) with CHF and RF for venous thrombosis. Follow-up lasted for 6 months. The following parameters were evaluated: overall mortality; overall mortality + thromboembolic complications. Results. Twelve (3.4%) patients died within the study period (8 patients in control group and 4 patients in Clexane group). Thromboembolic complications were observed in 19(5.4%)patients including 11 patients of the control group and 8 patients of the Clexane group, with the totality of 19 cases in the control group and 12 cases in the Clexane group. Therefore the enoxaparin therapy proved efficient in CHF patients at high risk of thrombus formation.

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