Russian Heart Failure Journal 2006year Lipid peroxidation chronic heart failure: an interrelationship with clinical parameters and effects of a standard therapy


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2006/

Lipid peroxidation chronic heart failure: an interrelationship with clinical parameters and effects of a standard therapy

Sitnikova M.Yu., Ivanov S.G., Shlyakhto E.V.

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Urgency. Despite the ambiguity in results of studies on the role of oxidative stress (OS) in CHF, most investigators admit an interrelationship between accumulation of OS products and CHF progression. The lack of a «gold standard» in determining products of free radical oxidation, particularly lipid peroxidation (LP), is an important factor which hampers validation of this concept. Aim: To study LP markers in patients with CHF in the course of long–term therapy with recommended β–adrenoblockers (BAB). Materials and methods. Sixty–two male patients with IHD and I–IV FC CHF, 10 patients with IHD without HF signs, and 20 healthy male subjects were evaluated. Levels of malonic dialdehyde (MDA) and activity of superoxide dismutase (SOD) were measured. Results. Blood level of MDA was increased in patients with CHF to higher values than in patients with IHD without CHF. This parameter was significantly lower in patients with CHF with and a high exercise tolerance and in patients receiving cardiac glycosides as a part of therapy. The SOD activity was lower in patients with CHF than in healthy subjects but higher than in patients with IHD not complicated with HF. An increased SOD activity was observed in patients with III and IV FC CHF, older patients, and patients with impaired exercise tolerance and sharply reduced LV systolic function. A 6–month therapy of CHF patients with carvedilol or metoprolol CR/XL resulted in changes in LP markers of the same direction, while in the absence BAB treatment, patients with CHF displayed a distinct trend to increasing blood levels of MDA.

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