Russian Heart Failure Journal 2006year Oxidative stress in chronic heart failure and type 2 diabetes mellitus (from results of program RAMBO)


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2006/

Oxidative stress in chronic heart failure and type 2 diabetes mellitus (from results of program RAMBO)

Arzamasieva N.E., Lankin V.S., Konovalova G.G., Tikhaze A.K., Ageev F.T., Lapina Yu.V., Narusov O.Yu., Mareev V.Yu., Belenkov Yu.N.

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Urgency. Oxidative stress plays an important role in pathogenesis of various cardiovascular diseases. Due to complicated and laborious methods for determining parameters characterizing the state of oxidative stress in vivo, only isolated studies have been performed up to the present on minimum contingents of patients, which have not always used adequate methods. This is why an open, prospective, randomized clinical study «RAtional, Effective Multi–component Therapy for Battle Over HF and DM» (RAMBO). Aim: To provide a clinical characteristic of patients with CHF, type 2 DM and combination of these diseases and to evaluate parameters of oxidative stress in dynamics in relation to severity of these diseases. Materials and methods. Study included 82 patients with II–III FC CHF, LV EF <45% and type 2 DM (group 1); patients with II–III FC and LV EF <45% without disturbances of carbohydrate metabolism (group 2), and 25 patients with type 2 DM without CHF symptoms and with preserved LV EF. Clinical condition of patients was determined by Clinical Condition Evaluation Scale (CCES); quality of life was evaluated using a special Minnesota questionnaire; level of brain natriuretic peptide (BNP) was measured; and parameters reflecting severity of oxidative stress were determined. Results. CHF was characterized by the presence of pronounced oxidative stress which was less severe in patients with type 2 DM. Processes of free radical oxidation were also not more intensive in the CHF+DM group than in the group of CHF patients. Severity of oxidative stress was apparently maximal in CHF, while type 2 DM which, according to our data, is characterized by much more intensive free radical oxidation than severe forms of chronic CHF, cannot considerably aggravate the existing extreme situation.

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