Russian Heart Failure Journal 2006year Clinical morphological parallels in patients with chronic heart failure of different functional classes
Clinical morphological parallels in patients with chronic heart failure of different functional classes
Rogov K.A., Kalmaeva O.V.
Urgency. CHF has been the most frequent cause of death, hospitalization and reduced quality of life in patients with cardiovascular diseases. The activation of RAAS underlying CHF development results in excessive collagen production and deposition in many organs and systems including kidneys. Aim. Studying the renal function in patients with CHF of different severity in their lifetime and autopsic measurement of collagen content in kidneys. Materials and methods. Thirty-one patients were enrolled in the study including 27 patients with CHF of different severity; control group consisted of 4 patients without IHD, CHF or renal disease. Evaluation of lifetime renal function included: measurement of blood creatine level, glomerular filtration rate (GFR), proteinuria and microalbuminuria (MAU). In lethal cases, morphometry of kidneys was conducted with measurement of collagen specific volume (CSV). Results. We observed a direct correlation between CHF duration, CHF FC and CSV in kidneys. Mean SCV was 0.118±0.005 in the control group. In the group of patients with I–II FC CHF and CHF duration of 2.4±1.2 years, mean CSV was significantly higher and comprised 0.190±0.004 (р<0.05). In the group with III–IV FC CHF and CHF duration of 6.5±1.8 years, mean CSV was 0.224±0.005, which was significantly higher than in the group of patients with milder course of CHF (р<0.05).