Russian Heart Failure Journal 2006year Dynamics of proinflammatory cytokine levels in patients with CHF depending on the administered treatment


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2006/

Dynamics of proinflammatory cytokine levels in patients with CHF depending on the administered treatment

Korochkin I.M., Oblokulov I.U., Fedulaev Yu.N.

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Urgency. Despite the abundance of drugs for the treatment of CHF, rational drug therapy has not been always administered correctly, especially with combination therapy. Aim. Evaluating the effect of combination treatment with helium–neon laser and a TNF–α inhibitor (trental) on the dynamics of proinflammatory cytokine and acute–phase protein levels, hemodynamics and clinical manifestations of CHF. Materials and methods. Study included 75 patients aged from 49 to 71 years with CHF (II–III degree circulatory insufficiency (CI)). Evaluation of the drug therapy efficacy included dynamics of proinflammatory cytokines (TNF–α, interleukin–6 (IL–6)), acute–phase proteins (CRP, fibrinogen, LDH), cardiac morpho–functional parameters and clinical manifestations of disease. Results. Patients with CHF (II–III degree CI) should receive combination drug therapy. The combination of standard therapy and intravenous laser blood irradiation (ILBI) using a low–intensity helium–neon laser and trental appeared the most effectiveone. The TNF–α and IL–6 levels decreased by 64.8 and 30.7% (p<0.001), respectively;
fibrinogen, CRP and LDH levels significantly decreased; EF increased by 13%; and LV anteroposterior shortening increased by 14.1%. Analyis of the LV diastolic function showed that the peak velocity of LV early filling (PVEF) increased by 13.8% and the peak velocity of LV late filling (PVLF) decreased by 9.8%. The elastic modulus (EM) and the coefficient of stiffness (CS) decreased by 12 and 15.7%, respectively.

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