Russian Heart Failure Journal 2005year Central and peripheral mechanisms in the pathogenesis of chronic heart failure
Central and peripheral mechanisms in the pathogenesis of chronic heart failure
Development of chronic heart failure (CHF) is impossible without a decrease in heart pump function which is determined by the efficiency of the heart systolic and diastolic function. Author considers major causes for left ventricular systolic and diastolic dysfunction. The inefficiency of systemic hemodynamics and the decreased tissue perfusion are accompanied by hypoxia and disturbed microcirculation. These processes result in dystrophy and dysfunction of internal organs along with inefficiency of energy production and energy consumption. In this process, the inefficiency of energy consumption is largely due to a specific rearrangement of structure and mass of muscular and fat tissue. The CHF symptomatology itself results from two components, dystrophy and dysfunction of internal organs and systems and also from decreased exercise tolerance.