Russian Heart Failure Journal 2005year The state of left ventricular function and activity of proinflammatory cytokines in acute myocardial infarction


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2005/

The state of left ventricular function and activity of proinflammatory cytokines in acute myocardial infarction

Zakirova A.N. , Mukhametrakhimova A.R., Zakirova N.E.

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Urgency. Major factors influencing the course and prognosis of MI include hemodynamic disorders with LV systolic dysfunction. Inflammatory reactions involving proinflammatory cytokines play an important role in destabilization of atherosclerotic plaques and development of MI. Studies evaluating the state of intracardiac hemodynamics and release of proinflammatory cytokines in MI in relation to the depth of lesion and outcome of disease, are absent. Aim. Studying the LV systolic function and activity of proinflammatory cytokines in patients with MI in relation to characteristics of course and outcome of disease. Material and methods. One hundred two patients with MI and 35 healthy subjects were evaluated. State of intracardiac hemodynamics was examined using echoCG. Levels of interleukin-1β and -6 (IL-1β; IL-6) and tumor necrosis factor-α (TNF-α) were measured using immunoenzyme assay. Results. Complicated course of Q-MI was associated with considerable disorders of LV systolic function evident as the increased volume and reduced EF of LV. The MI was characterized by activation of IL-1β and IL-6 along with deficient TNF-α production. Changes in cytokine levels were coupled with the depth of lesion, severity of course and outcome of MI. Decreased cytokine levels were noted in fatal outcome of MI in contrast to a significant cytokine increase in survived patients. Conclusions. Disorders of LV systolic function and activation of proinflammatory cytokines significantly contribute to the formation of MI clinical course. Low levels of cytokines are associated with severe course of MI and represent predictors of unfavorable outcome.

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