Russian Heart Failure Journal 2005year Correction of systemic inflammation by the method of nutritive support in patients with III–IV FC CHF


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2005/

Correction of systemic inflammation by the method of nutritive support in patients with III–IV FC CHF

Kostyukevich O.I., Khadyshjyan G.G.

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Urgency: CHF is presently regarded as a systemic disease. A leading factor in CHF pathogenesis along with activation of neuro-humoral systems is the systemic inflammatory response. In this process, the higher CHF FC the higher level of proinflammatory cytokines, which reaches maximum in patients with signs of cardiac cachexy and predetermines an unfavorable survival prediction. Aim: Studying the dynamics of serum markers for systemic inflammation in patients with CHF during the use of a mixture for enteral nutrition Modulen IBD possessing an anti-inflammatory effect. Materials and methods: Study included III–IV FC CHF patients with decreased lean body mass (LBM) and a level of C-reactive peptide (CRP) above 5 mg/dl. In total 69 patients aged 63.1±6.3 years were enrolled. Control group consisted of 32 patients receiving a standard therapy and nutrition by diet No. 10. Main group included 37 patients receiving in addition to the standard therapy Modulen IBD for 4 weeks. Level of CRP, LBM and body mass index (BMI) were measured. Exercise tolerance was evaluated using the 6-min walking test. Results: At baseline the level of CRP in patients with III-IV FC CHF was 8.4±0.6 mg/l, which was more than twofold higher than normal. After 4 weeks of therapy, the level of CRP in patients receiving Modulen IBD decreased by 16.4%.

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