Russian Heart Failure Journal 2005year Qualitative and quantitative parameters of large intestinal microflora in different functional classes of chronic heart failure
Qualitative and quantitative parameters of large intestinal microflora in different functional classes of chronic heart failure
Arutyunov G.P., Kafarskaya L.I., Bylova N.A., Chernyavskaya T.K., Pokrovsky Yu.A., Korsunskaya M.I., Chernaya Z.A.
Urgency. In recent years, increasing attention has been paid to development of intoxication in CHF. Some authors have put forward a hypothesis on the role of bacterial flora in development of the intoxication syndrome. Aim of study: Evaluating the microbiocenosis in intestinal parietal layer and feces and also the levels of endotoxin and proinflammatory cytokines in patients with different CHF FC as compared with age-matched healthy subjects. Materials and methods. Study included 37 patients with CHF of ischemic genesis and 13 healthy volunteers. All patients underwent the following examinations: 6-min test; echoCG evaluation of LV EF; clinical status by SECS scale (Scale for evaluation of clinical state), measurement of C-reactive peptide; LAL test; faeces plating on selective growth media with further incubation and evaluation of results; colonoscopy with sampling and plating on growth media. Results. Data showed increased concentrations of gram-negative organisms in both large intestine lumen and parietal layer correlating with severity of HF. Increased levels of circulating endotoxin and C-reactive peptide were also observed in patients with III–IV FC CHF.