Russian Heart Failure Journal 2005year Dose-dependent effect of long-term therapy with AT1 angiotensin II receptor antagonists in patients with CHF and intolerance of ACEI
Dose-dependent effect of long-term therapy with AT1 angiotensin II receptor antagonists in patients with CHF and intolerance of ACEI
Alikhanova L.T., Rylova A.K., Rylova N.V., Mordasova O.P.
Urgency. ACE inhibitors (ACEI) are a part of standard therapy for CHF. The ACEI intolerance of some patients puts forward a question on the use of AT1 AII receptor antagonists (ARA) for the treatment of CHF. Aim of study. Evaluating the clinical efficacy of «high» ARA doses in comparison with «low» ARA doses in patients with severe CHF and ACEI intolerance. Materials and methods. Sixty-three patients with CHF and ACEI intolerance were treated with drugs of the ARA group at different doses for one year. Dynamics of CHF FC, LV EF, 6-min walking test and aldosterone levels were determined. Results. The long-term application of «high» dose ARA decreased CHF FC by 20%, increased LV EF by 6%, enhanced exercise tolerance (6-min test) by 28%, and reduced the blood level of aldosterone by 34%.