Russian Heart Failure Journal 2005year Left ventricular diastolic dysfunction and exercise tolerance in elderly
Left ventricular diastolic dysfunction and exercise tolerance in elderly
Sumin A.N., Gayfulin R.A., Galimzyanov D.M.
Urgency. Decreased exercise tolerance in elderly may be due both to diastolic dysfunction and alterations of peripheral tissues. Aim: Studying interrelations of intracardiac hemodynamic parameters and condition of peripheral tissues and the exercise tolerance in healthy elderly patients. Material and methods. Forty healthy subjects including 20 subjects older than 60 years (68.0±7.5 years) and 20 subjects younger than 60 years (45.9±5.9 years) were evaluated. All subjects underwent an examination including exercise tests (bicycle ergometry, 6-min walking, statico-dynamic and static tests, handgrip dynamometry, respiratory muscle force) echoCG and evaluation of endothelial function. Results. The age-dependent decrease in exercise tolerance was associated with the reduced force and endurance of skeletal muscles, impaired parameters of filling (velocity of intraventricular flow propagation, isovolumic relaxation time, and Е/А ratio) and LV structural parameters (wall thickness and weight of myocardium). Multiple stepwise regression analysis showed that the exercise tolerance in bicycle ergometry was primarily determined by the condition of skeletal muscles and parameters of LV diastolic function. In the 6-min walking test the exercise tolerance was determined by force and endurance of skeletal muscles and LV myocardium weight.