Russian Heart Failure Journal 2005year Velocity of pulse wave propagation in evaluation of endothelial dysfunction in patients with chronic heart failure of ischemic etiology


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2005/

Velocity of pulse wave propagation in evaluation of endothelial dysfunction in patients with chronic heart failure of ischemic etiology

Ilyukhin O.V., Ilyukhina M.V., Kalganova E.L., Ivanenko V.V., Lopatin Yu.M.

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Urgency. Endothelial dysfunction (ED) in patients with heart failure is above any doubt. Moreover the chronic heart failure itself (CHF) will facilitate development and progression of ED in every possible way. Principal ways for ED evaluation often cannot be used as routine methods of functional diagnostics in real clinical practice. Response of a conduit artery to the reactive hyperemia (RH) test can be assessed by the pulse wave velocity (PWV). Aim. To study a possibility of detecting endothelial dysfunction in CHF of ischemic etiology using assessment of changes in the velocity of pulse wave propagation in the reactive hyperemia test. Materials and methods. Fifty-six patients with I–IV NYHA functional class (FC) CHF matched by major clinical parameters were enrolled in the study. The PWV was measured using a computerized device Colson. Endothelial function was evaluated by changes in PWV in response to an increase in blood flow during the RH test. Results. In all patients with CHF the PWV in elastic type arteries was significantly higher than in the control group but it did not increase with increasing CHF FC. ED was revealed in most patients with CHF and it was the most pronounced at the highest CHF FC. A paradoxical increase in PWV in response to the RH test was observed much more frequently in patients with III–IV FC CHF. A significant correlation between the radial artery CHF FC and the relative decrease in PWV was observed in the RH test (r=0.58, p<0.05). Results of the study show a principal possibility for evaluation of ED in patients with CHF of ischemic etiology by measurements of PWV in response to RH.

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