Russian Heart Failure Journal 2004year Effect of monopril on endothelial dysfunction in patients with arterial hypertension


To access this material please log in or register

Register Authorize
2004/

Effect of monopril on endothelial dysfunction in patients with arterial hypertension

Kirichenko L.L., Dvoryanchikova Zh.Yu., Sharandak A.P., Tseka O.S., Korolev A.P., Kuznetsova L.F., Puryaeva N.L.

Keywords:

DOI:

Study evaluated the effect of the ACE inhibitor (ACEI) fosinopril on vascular platelet hemostasis in patients with arterial hypertension. Sixty-four patients with degree 1 and 2 arterial hypertension were evaluated. It was shown that an efficient 6-month therapy with fosinopril resulted in significant improvement of ADP-induced platelet aggregation. After 12 months of treatment, significant decreases were observed in spontaneous aggregation and thromboxane level and a significant increase in nitric oxide metabolites. A trend toward an increase in prostacyclin level was noted.

To access this material please log in or register

Register Authorize
Ru En