Russian Heart Failure Journal 2004year Clinical and prognostic significance of brain natriuretic peptide in patients who have undergone revascularization surgery and heart valve prosthetics
Clinical and prognostic significance of brain natriuretic peptide in patients who have undergone revascularization
surgery and heart valve prosthetics
Moroz-Vodolazhskaya N.N., Kardash O.F., Kolyadko M.G., Kurganovich S.A., Yasko T.G., Ostrovsky A.Yu., Tyashkevich N.N., Ostrovsky Yu.P.
Urgency. Brain natriuretic peptide (BNP) is produced in cardiomyocytes under the conditions of transmural stress. Plasma level of the hormone correlates with degrees of left ventricular (LV) dysfunction, heart failure (HF) and predicted course of acute and chronic forms of HF. Aim of the study was determining the clinical and prognostic implication of BNP in patients with HF caused by IHD or acquired defects of heart valves (rheumatism, infectious endocarditis), who had undergone aortocoronary bypass (ACB) or heart valve prosthetics. Materials and methods. 68 patients with HF (I–IV NYHA FC) resulting from ischemic heart disease (IHD) and with acquired defects of heart valve (rheumatism, infectious endocarditis) and plasma BNP 17–1300 pg/ml (Triage Bioset) were evaluated. Results. In cardiosurgical patients with HF of ischemic genesis, BNP level was related with systolic and diastolic dysfunction. In patients with BNP>500 pg/ml, BNP level was related with HF FC, pulmonary systolic blood pressure (PSBP) and adverse outcome of the surgery.