Russian Heart Failure Journal 2004year Study of efficacy and safety of long-term, well-dosed exercise training as a part of complex therapy in patients with III–IV FC CHF


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2004/

Study of efficacy and safety of long-term, well-dosed exercise training as a part of complex therapy in patients with III–IV FC CHF

Chernyavskaya T.K., Volgina O.N.

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Aim: To study efficacy and safety of long-term, well-dosed exercise training in patients with III–IV functional class (FC) chronic heart failure (CHF). Material and methods: Patients with III–IV FC CHF and left ventricular (LV) ejection fraction (EF) <40% were enrolled in the study. Patients of Group 1 (n=164) received a standard drug therapy for CHF; patients of Group 2 (n=123) received a combination of standard drug therapy for CHF and well-dosed exercise training. Dynamics of 6-min test, microalbuminuria (MAU) and quality of life was evaluated. Results of study: A significant positive dynamics of 6-min test was achieved in the group of patients treated with exercise training. At 12 and 36 months the parameter increased by 21.4% and 43.7% in patients with III FC and by 46.3% and in 95.7% of patients with IV FC, respectively. At 6 months of follow-up, the patients displayed a significant improvement in quality of life. No significant between-group difference in dynamics of body mass was observed for 36 months of follow-up. An increase in MAU was noted in both groups in the follow-up period: by 27.7% in Group 1 and by 34.6% in Group 2 for 36 months. There were no significant between-group differences in MAU dynamics.

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