Russian Heart Failure Journal 2004year The use of natriuretic peptide precursors in diagnostics of heart failure of ischemic etiology before and after aortocoronary bypass surgery
The use of natriuretic peptide precursors in diagnostics of heart failure of ischemic etiology before and after aortocoronary bypass surgery
Bokeriya L.A., Golukhova E.Z., Eremeeva M.V., Polyakova E.S., Kakuchaya T.T.
Urgency. Abundant results of epidemiological studies evidence that ischemic heart disease (IHD) is presently the major cause for development and progression of heart failure (HF). Therefore timely diagnostics of HF is very important. In this connection, a search for universal laboratory HF markers is of special interest, with natriuretic peptides (NPs) among the major candidate markers. Aim. Evaluating a possibility for using the NP precursors proANP and proBNP as HF markers in patients with IHD before and after surgical intervention and studying the effect of surgical myocardial revascularization on plasma levels of NP precursors in patients with IHD. Material and methods. 70 patients with IHD were enrolled in the study. 30 patients underwent aortocoronary bypass (ACB) in the conditions of artificial circulation (AC). ProANP and proBNP were measured in plasma of patients before the surgery and 14–16 days after the surgery. Results. NP precursors allowed diagnosing HF at early stages of disease. A good correlation between levels of NP precursors and several EchoCG parameters was shown. In the early ACB postoperative period, levels of proANP and proBNP significantly increased in the absence of HF symptom progression, which might be due, at least partially, to development of systemic inflammatory syndrome following AC. In order to verify this hypothesis, the started studies should be continued.