Russian Heart Failure Journal 2004year Efficacy of metoprolol CR/XL in complex therapy of heart failure complicated with atrial fibrillation
Efficacy of metoprolol CR/XL in complex therapy of heart failure complicated with atrial fibrillation
Baleeva L.V., Galyavich A.S.
Urgency. Atrial fibrillation (AF) is a common and severe disorder of heart rhythm. AF impairs hemodynamics, reduces exercise tolerance and decreases quality of life. Therapy for AF is still rather empirical. Aim. Evaluating the efficacy of metoprolol CR/XL in complex therapy for chronic heart failure complicated with AF. Materials and methods. 80 patients with AF having lasted for 6.6±3.2 years were divided into 2 groups: patients of the first group (n=40) received metoprolol CR/XL (mean dose 63±42 mg/day) on the background of previous standard therapy. Patients of the second (control) (n=40) group continued on the previous routine therapy for CHF. Follow-up period lasted for 6 months. Clinical evaluation, echoCG, 6-min walking test and evaluation of quality of life were performed. Results. Addition of metoprolol CR/XL at low doses to the therapy resulted in improvements of clinical condition, quality of life, hemodynamic parameters and exercise tolerance in patients with CHF. The effect did not depend on dose of the drug and was most distinct in patients with pronounced CHF. The group of patients not receiving metoprolol therapy displayed a trend to worsening of the parameters.