Russian Heart Failure Journal 2004year Intestinal biocenosis and cardiovascular continuum


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2004/

Intestinal biocenosis and cardiovascular continuum

Arutyunov G.P., Kafarskaya L.I., Vlasenko V.K., Pokrovsky Yu.A., Kostyukevich O.I., Chernaya Z.A.

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Despite progress in studies on the pathogenesis of chronic heart failure (CHF) and appearance of pathogenetic approaches to the treatment, prognosis in CHF patients has not significantly changed in the past two decades. In recent time a serious attention has been given to fluctuations of cytokine level depending on severity of symptoms and CHF functional class (FC). Many studies have shown sinusoidal changes in cytokine levels in CHF with the fluctuations consistent to clinical periods of the presence or absence of control to the patient condition. Congestive events in systemic circulation (SC) result in maximum activation of the immune system in CHF. The presence of edema of the mucous, along with the collagen deposition processes in intestinal walls disturbing the structure of intestinal wall layers, results in increased permeability of the intestinal wall for bacterial endotoxin, which represents a potent activator of the immune system. Therefore it is necessary to study in detail the methods of affecting gastrointestinal (GI) microflora, which is a major source of endotoxin entering the internal environment of the organism, and also methods for restoration of normal permeability in order to reduce the intensity of systemic inflammatory processes.

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