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Age-Related Changes of Heart Rate Variability at Various Insulin Sensitivity and Telomere Length

Streltsova L. I.1, Tkacheva O. N.1, 2, Dudinskaya E. N.1, 2, Akasheva D. U.1, Plokhova E. V.1, 2, Strazhesko I. D.1, Boytsov S. A.1
1Federal State Institution National Research Center for Preventive Medicine, Moscow, Russia 2Russian Gerontology Research Center, Moscow, Russia

Keywords: age; heart rate variability; telomeres; insulin sensitivity

DOI: 10.18087/cardio.2017.7.10006

Aim. To study relationship between age-associated changes of heart rate variability (HRV), telomere length (TL), and lowering of insulin sensitivity (IS). Material and methods. We included in this study 229 individuals aged 23‒91 years without clinical manifestations of cardiovascular and other somatic diseases. In all participants, we analyzed HRV parameters obtained at 24-hour ECG monitoring (24-h ECG) and 5 minutes ECG recordings in the supine and standing positions. Leukocyte TL was estimated on genomic DNA using real time polymerase chain reaction. Insulin sensitivity was characterized by calculation of НОМА-IR and Gutt's insulin sensitivity index (ISI). Results. Elderly people with short telomeres (<9.80 arbitrary units) had lower values of SDNN, RMSSD, TP, VLF compared with people of the same age group with long telomeres (≥9.80 arbitrary units). In the group of elderly persons with HOMA-IR ≥2.5 individuals with short telomeres had lower values of TP in supine and standing positions, LF in supine and HF in standing positions than individuals with long telomeres. Among persons aged ≥60 years and low ISI (<103.67) HRV parameters (SDNN, SDANN, RMSSD, TP, VLF) obtained from 24-h ECG in groups of short and long telomeres were significantly different. TL was found to be independently related to SDNN and VLF when age, gender and ISI were taken into account. Conclusion. Presumably age-associated changes of vegetative regulation of cardiac rhythm could be related to cellular aging of neurons of the vegetative nervous system (VNS) and cardiomyocytes. However, mechanism of this relationship remains not completely elucidated. Shorter telomeres in individuals aged ≥60 years without cardiovascular diseases are associated with lowered VNS tone and relative preponderance of sympathetic regulation. At the same time, long telomeres and lowered ISI were found to be associated with higher HRV parameters than short telomeres and lowered ISI.
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Streltsova L. I., Tkacheva O. N., Dudinskaya E. N., Akasheva D. U., Plokhova E. V., Strazhesko I. D., Boytsov S. A. Age-Related Changes of Heart Rate Variability at Various Insulin Sensitivity and Telomere Length. Kardiologiia. 2017;57(7):52–60.

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