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Sudden Cardiac Death in Patients With Ischemic Heart Disease: From Mechanisms to Clinical Practice

Golukhova E. Z., Gromova O. I., Bulaeva N. I., Bokeria L. A.
A. N. Bakoulev Scientific Center for Cardiovascular Surgery, Moscow, Russia

Keywords: sudden cardiac death; ventricular tachyarrhythmias; acute myocardial ischemia; arrhythmogenic substrate; implantable cardioverter defibrillator

DOI: 10.18087/cardio.2017.12.10069

Ischemic heart disease (IHD) and acute coronary syndrome are the main cause of sudden cardiac death (SCD). Incidence of SCD in patients after myocardial infarction (MI) is 4-6-fold higher than in general population. The review focuses on electrophysiological changes during acute myocardial ischemia and mechanisms of myocardial electromechanical remodeling in remote period after MI. Current data on arrhythmia substrates and triggers are presented. Nowadays, the main guide for implantable cardioverter-defibrillator (ICD) use for primary prevention of SCD is reduced left ventricular ejection fraction. The significance of this parameter has been repeatedly demonstrated in large randomized studies. However, the use of a single indicator cannot solve the problem. In this review we present analysis of modern additional predictors of fatal arrhythmias which are available in clinical practice, as well as the perspective for further research of this highly important scientific, clinical, and social problem.
  1. Gillum R. F. Geographic variation in sudden coronary death. Am Heart J 1990;119 (2 Pt 1):380–389.
  2. Golukhova E. Z. Sudden cardiac death. Can results of randomized trials change our understanding of possible predictors and ways of prevention? Kreativnaya kardiologiya 2008;1:7–24. Russian (Голухова Е. З. Внезапная сердечная смерть. Меняют ли результаты рандомизированных исследований наши представления о возможных предикторах и путях профилактики? Креативная кардиология 2008;1:7–24).
  3. Boytsov S. A., Nikulina N. N., Yakushin S. S. et al. Sudden cardiac death in patients with coronary heart disease: results of the Russian multi-centre epidemiological study of mortality, morbidity, and diagnostics and treatment quality in acute CHD (RESONANCE). Russian Journal of Cardiology. 2011; (2):59–64. DOI: 10.15829/1560‑4071‑2011‑2‑59‑64. Russian (Бойцов С. А., Никулина Н. Н., Якушин С. С. и др. Внезапная сердечная смерть у больных ишемической болезнью сердца: по результатам Российского многоцентрового эпидемиологического исследования заболеваемости, смертности, качества диагностики и лечения острых форм ИБС (РЕЗОНАНС). Российский кардиологический журнал 2011;2:59–64. DOI: 10.15829/1560‑4071‑2011‑2‑59‑64)
  4. Fishman G. I., Chugh S. S., DiMarco J. P. et al. Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop. Circulation 2010;122:2335–2348.
  5. Goldberger J. J., Cain M. E., Hohnloser S. H. et al. American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death. J Am Coll Cardiol 2008;52:1179–1199.
  6. Santini M., Lawalle C., Ricci R. P. Primary and secondary prevention of SCD: who should get an ICD? Heart 2007;93:1478–1483.
  7. Moss A. J., Hall W. J., Cannom D. S. et al. Multicenter Automatic Defibrillator Implantation Trial Investigators. Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. N Engl J Med 1996;335:1933–1940.
  8. Moss A. J., Zareba W., Hall W. J. et al. Multicenter Automatic Defibrillator Implantation Trial II Investigators. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 2002;346:877–883.
  9. Nieminen T., Lehtima T., Viik J. et al. T-wave alternans predicts mortality in a population undergoing a clinically indicated exercise test. Eur Heart J 2007;28:2332–2337.
  10. Bardy G. H., Lee K. L., Mark D. B. et al. Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 2005;352:225–237.
  11. Rubart M., Zipes D. P. Mechanisms of sudden cardiac death. J Clin Invest 2005;115:2305–2315.
  12. Myerburg R. J., Interian A., Simmons J., Castellanos A. Sudden cardiac death. In: Zipes DP, ed. Cardiac Electrophysiology: from Cell to Bedside. 4th ed. Philadelphia: WB Saunders; 2004: 720–731.
  13. George A. L. Jr. Molecular and genetic basis of sudden cardiac death. J Clin Invest 2013;123:75–83. doi: 10.1172/JCI62928
  14. Shmidt A., Azevedo C. F., Cheng A. et al. Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation 2007;115:2006–2014.
  15. Nguyen T. P., Qu Z., Weiss J. N. Cardiac Fibrosis and Arrhythmogenesis: The Road to Repair is Paved with Perils. J Mol Cell Cardiol 2014;70:83–91.
  16. Caron K. M., James L. R., Kim H. S. et al. Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene. Proc Nat Acad Sci USA 2004;101:3106–3111.
  17. Donoghue M., Wakimoto H., Maguire C. T. et al. Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins. J Mol Cell Cardiol 2003;35:1043–1053.
  18. Pitt B., Zannand F., Remme W. et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. New Engl J Med 1999;341:709–717.
  19. Sokol’skaya M. A. Aldosterone antagonists at prevention of sudden cardiac death. Annali arrhythmologii. 2006;4:49–56. Russian (Сокольская М. А. Антагонисты альдостерона в профилактике внезапной сердечной смерти. Анналы аритмологии 2006;4:49–56).
  20. Tikhomirova V. E., Kryukova O. V., Serov R. A. et al. Phenotyping of Angiotensin-Converting Enzyme in the Human Heart. JACC 2015;6 (10S).
  21. Zipes D. P., Rubart M. Neural modulation of cardiac arrhythmias and sudden cardiac death. Heart Rhythm 2006;3:108–113.
  22. Revishvili A. Sh., Ardashev A. V., Boytsov S. A. et al. All-Russian Scientific Society of Specialists on Clinical Electrophysiology, Arrhythmology and Pacing. Clinical guidelines for electrophysiological studies, catheter ablation and implantable antiarrhythmic devices. 3rd ed. Мoscow: MAKS Press; 2013: 596 p. Russian (Ревишвили А. Ш., Ардашев А. В., Бойцов С. А. и др. Клинические рекомендации по проведению электрофизиологических исследований, катетерной аблации и применению имплантируемых антиаритмических устройств. М.: МАКС Пресс; 2013. 596 с.).
  23. Tracy C. M., Epstein A. E, Darbar D. et al. 2012 ACCF/AHA/HRS Focused Update incorporated into the ACCF/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and Heart Rhythm Society. J Am Coll Cardiol 2013;61:e6–e75.
  24. Priori S. G., Blomstrom-Lundqvist C., Mazzanti A. et al. ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death Eur Heart J 2015;36:2793–2867 doi: 10.1093/eurheartj/ehv316.
  25. Hohnloser S. H., Kuck K. H., Dorian P., et al for the DINAMIT Investigators. Prophylactic Use of an Implantable Cardioverter – Defibrillator after Acute Myocardial Infarction. N Engl J Med 2004;351:2481–2488.
  26. Bigger J. T. Jr., Whang W., Rottman J. N. et al. Mechanisms of death in the CABG Patch trial: a randomized trial of implantable cardiac defibrillator prophylaxis in patients at high risk of death after coronary artery bypass graft surgery. Circulation 1999;99:1416–1421.
  27. Gorgels A. P., Gijsbers C., de Vreede-Swagemakers J. et al. Out-ofhospital cardiac arrest – the relevance of heart failure. The Maastricht Circulatory Arrest Registry. Eur Heart J 2003;24:1204–1209.
  28. Groh W. J. Lessons from a population: the limitations of left ventricular ejection fraction as the major determinant for primary prevention implantable cardioverter-defibrillators. J Am Coll Cardiol 2006;47:1167–1168.
  29. Stecker E. C., Vickers C., Waltz J. et al. Population-based analysis of sudden cardiac death with and without left ventricular systolic dysfunction: two-year findings from the Oregon Sudden Unexpected Death Study. J Am Coll Cardiol 2006; 47:1161–1166.
  30. Pillarisetti J., Emert M., Biria M. et al. Under-Utilization of Implantable Cardioverter Defibrillators in Patients with Heart Failure – The Current State of Sudden Cardiac Death Prophylaxis. Indian Pacing Electrophysiol J 2015;15:20–29.
  31. Shah B., Hernandez A. F., Liang L. Get With The Guidelines Steering Committee. Hospital variation and characteristics of implantable cardioverter-defibrillator use in patients with heart failure: data from the GWTG-HF (Get With The Guidelines-Heart Failure) registry. J Am Coll Cardiol 2009;53:416–22.
  32. Costantini O., Hohnloser S. H., Kirk M. M. et al. The ABCD (Alternans Before Cardioverter Defibrillator) Trial: strategies using T-wave alternans to improve efficiency of sudden cardiac death prevention. J Am Coll Cardiol 2009;53:471–479.
  33. Gromova O. I., Aleksandrova S. A., Makarenko V. N., Golukhova E. Z. Contemporary predictors of life threatening arrhythmias. Kreativnaya kardiologiya.2012;2:30–46. Russian (Громова О. И., Александрова С. А., Макаренко В. Н., Голухова Е. З. Современные предикторы жизнеугрожающих аритмий. Креативная кардиология 2012;2:30–46).
  34. Goldberger J. J, Cain M. E., Hohnloser S. H. et al. American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death. J Am Coll Cardiol 2008;52:1179–1199.
  35. Scott P. A., Barry J., Roberts P. R., Morgan J. M. Brain natriuretic peptide for the prediction of sudden cardiac death and ventricular arrhythmias: a meta-analysis. Eur J Heart Fail 2009;11:958–966.
  36. Golukhova E. Z., Gromova O. I., Merzlyakov V. Yu. et al. Heart rate turbulence and brain natriuretic peptide level as predictors for lifethreatening arrhythmias in patients with coronary artery disease. Kreativnaya kardiologiya 2013;2:62–77. Russian (Голухова Е. З., Громова О. И., Мерзляков В. Ю. и др. Турбулентность ритма сердца и мозговой натрийуретический пептид как предикторы жизнеугрожающих аритмий у больных ишемической болезнью сердца. Креативная кардиология 2013;2:62–77).
  37. Kanoupakis E. M., Manios E. G., Kallergis E. M. et al. Serum Markers of Collagen Turnover Predict Future Shocks in Implantable Cardioverter-Defibrillator Recipients With Dilated Cardiomyopathy on Optimal Treatment. J Am Coll Cardiol 2010;55:2753–2759.
  38. Marcus G. M. Can Serologic Markers of Fibrosis Reveal an Arrhythmogenic Ventricular Substrate in Nonischemic Dilated Cardiomyopathy? J Am Coll Cardiol 2010;55.№24. Editorial comment.
  39. Catalano O., Moro G., Perotti M. et al. Late gadolinium enhancement by cardiovascular magnetic resonance is complementary to left ventricle ejection fraction in predicting prognosis of patients with stable coronary artery disease. J Cardiovasc Magn Reson 2012;14:29. doi: 10.1186/1532-429X-14–29.
Golukhova E. Z., Gromova O. I., Bulaeva N. I., Bokeria L. A. Sudden Cardiac Death in Patients With Ischemic Heart Disease: From Mechanisms to Clinical Practice. Kardiologiia. 2017;57(12):73–81.

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