2017

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2017/№12

Elevated Level of the Natriuretic Peptide Among Adult Population in Regions Participating in the ESSE-RF Study and Its Association With Cardiovascular Diseases and Risk Factors

Shalnova S. A.1, Imaeva A. E.1, Deev A. D.1, Metelskaya V. A.1, Muromtseva G. A.1, Konradi A. O.2, Masenko V. P.3, Efanov A. Yu.4, Kulakova N. V.5, Rotar O. P.2, Trubacheva I. A.6, Shabunova A. A.7, Shlyakhto E. V.2, Boytsov S. A.1 on Behalf of the ESSE-RF Study Participants
1 Federal State Institution National Research Center for Preventive Medicine, Moscow, Russia
2 Federal Almazov North-West Medical Research Centre, Saint-Petersburg, Russia
3 National Medical Research Center for Cardiology, Moscow, Russia
4 Tyumen State Medical University, Tyumen, Russia
5 Vladivostok State Medical University, Vladivostok, Russia
6 Cardiology Research Institute, Tomsk, Russia
7 Institute for Social and Economic Development of the Territories, Vologda, Russia

Keywords: brain natriuretic peptide; cardiovascular diseases; RF population

DOI: 10.18087/cardio.2017.12.10065

Aim: to study associations between elevated blood plasma concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP), risk factors and cardiovascular diseases (CVD) in samples of adult population of Russian Federation (RF) aged 25–64 years. Materials and Methods. We analyzed data of examination of representative samples of population of 5 regions of RF obtained within the framework of the multicenter ESSE-RF study (2012–2013). Number of examined subjects was 8 077 (3 176 men). Methods included use of standard questionnaire, measurements of height, body mass, blood pressure (BP), and plasma NT-proBNP level. The following CVD were included into analysis: arterial hypertension (AH), ischemic heart disease (IHD), atrial fibrillation (AF), and stroke. Results. Women compared to men had higher NT-proBNT concentration was higher in women compared to men, in both genders it rose with age. Overall 17.9 % of examinees had elevated NT-proBNT levels (14.2 and 20.3 % among men and women, respectively). Elevated NTproBNP level was associated in men with age, myocardial infarction, angina pectoris, ischemic ECG changes, left ventricular hypertrophy, AF, bradycardia, smoking, in women with age, IHD, ischemic ECG changes, AF, bradycardia, heart rate ≥80 bpm, BP ≥160/95 mm Hg. Conclusion. In studied RF population elevated NT-proBNP level was significantly associated with gender, age, smoking, and CVD.
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Shalnova S. A., Imaeva A. E., Deev A. D., Metelskaya V. A., Muromtseva G. A., Konradi A. O., Masenko V. P., Efanov A. Yu., Kulakova N. V., Rotar O. P., Trubacheva I. A., Shabunova A. A., Shlyakhto E. V., Boytsov S. A. on Behalf of the ESSE-RF Study Participants. Elevated Level of the Natriuretic Peptide Among Adult Population in Regions Participating in the ESSE-RF Study and Its Association With Cardiovascular Diseases and Risk Factors. Kardiologiia. 2017;57(12):43–52.

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